Quantitative and qualitative alterations of acute-phase proteins in healthy elderly persons
| Autor: | Debra Rzewnicki, Sally L. Hodder, Amasa B. Ford, Stanley P. Ballou, Lorraine C. Mion, Jean D. Sipe, Gerard Lozanski, Irving Kushner |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Aging Activities of daily living Adolescent Physiology Orosomucoid Reference Values Activities of Daily Living Immune Tolerance Medicine Humans Prospective Studies Prospective cohort study Serum Amyloid A Protein Aged Aged 80 and over biology business.industry C-reactive protein Acute-phase protein General Medicine Healthy elderly Middle Aged C-Reactive Protein Ageing Immunology biology.protein Female Geriatrics and Gerontology business Acute-Phase Proteins |
| Zdroj: | Age and ageing. 25(3) |
| ISSN: | 0002-0729 |
| Popis: | To assess acute-phase proteins in relation to ageing, we measured serum concentrations of C-reactive protein of AGP in 131 healthy elderly individuals (aged >/= 65 years) living independently in the community, and 47 healthy younger individuals. Concentrations of CRP in the older persons (median = 3.0 microg/ml) were significantly greater than in the younger group (median = 0.9 microg/ml, p = 0. 0003). Concentrations of SAA and AGP were similar in the two groups, but AGP glycosylation forms with reduced binding affinity for concanavalin-A (changes that have been observed in chronic inflammatory states) were increased in the elderly sample (p |
| Databáze: | OpenAIRE |
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