Absence of analgesic effect of intravenous melatonin administration during daytime after laparoscopic cholecystectomy: a randomized trial
| Autor: | Mads U. Werner, Jacob Rosenberg, Bülent Kücükakin, Lars Peter Holst Andersen, Ismail Gögenur |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
medicine.medical_specialty Visual analogue scale Analgesic Placebo law.invention Melatonin Intraoperative Period Young Adult Randomized controlled trial Double-Blind Method law medicine Humans Infusions Intravenous Laparoscopic cholecystectomy Aged Pain Measurement Pain Postoperative business.industry Analgesics Non-Narcotic Middle Aged Surgery Regimen Anesthesiology and Pain Medicine Cholecystectomy Laparoscopic Anesthesia Female business Sleep Surgical incision medicine.drug |
| Zdroj: | Journal of clinical anesthesia. 26(7) |
| ISSN: | 1873-4529 |
| Popis: | Study Objective To investigate whether melatonin administered intraoperatively reduced pain following laparoscopic cholecystectomy. Design Randomized, placebo-controlled, double-blinded study. Setting Two surgical departments in Copenhagen. Patients 44 women between 18 and 70years of age, who were surgical candidates for laparoscopic cholecystectomy. Interventions Patients were anesthetized by a standard protocol and received a standard multimodal postoperative analgesic regimen. Patients undergoing surgery were admitted on the day of surgery and were discharged the day after surgery. Ten mg of intravenous (IV) melatonin or placebo were administered at the time of surgical incision. Measurements Pain was assessed by a set of questionnaires documenting "pain at rest" using a visual analog scale (VAS). The use of rescue medication was recorded. Sleep quality and general well-being were measured on separate VAS scales. Sleepiness was assessed by the Karolinska Sleepiness Scale. Main Results Forty-four patients were included and randomized to the study. Three patients did not complete the study. No differences in VAS pain scores, sleep quality, general well-being, or sleepiness were found between the two groups in the postoperative period. The use of postoperative rescue medication did not differ between the groups. Conclusions The use of 10mg of IV melatonin administered during laparoscopic cholecystectomy did not affect postoperative pain or use of analgesic medication. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect