Practical one-step glucuronidation via biotransformation
| Autor: | Mie Fujiwara, Takashi Ohnuki, Ejiri Masahiko, Takahide Nishi, Masaaki Kizuka |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Clinical Biochemistry
Acyl glucuronide Glucuronidation Pharmaceutical Science One-Step 01 natural sciences Biochemistry Streptomyces Structure-Activity Relationship Glucuronides Biotransformation Present method Drug Discovery Humans Molecular Biology Dose-Response Relationship Drug Molecular Structure biology 010405 organic chemistry Chemistry Organic Chemistry biology.organism_classification Combinatorial chemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry Molecular Medicine |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 29:199-203 |
| ISSN: | 0960-894X |
| Popis: | We herein report a practical one-step glucuronidation method by biotransformation using Streptomyces sp. SANK 60895. This novel direct method of biotransformation has been shown to be more practical and scalable for glucuronidation than previously reported chemical and enzymatic procedures given its simplicity, high β-selectivity, cost-effectiveness, and reproducibility. We applied the present method to the synthesis of acyl glucuronide and hydroxy-β-glucuronide of mycophenolic acid and compound 4, respectively. This method was also shown to be applicable to the N-glucuronidation of various compounds. |
| Databáze: | OpenAIRE |
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