Deprecating the diagnostic significance of free thyroxine levels in human serum
| Autor: | M A Al-Awqati, Mithal Hassan |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
030213 general clinical medicine
medicine.medical_specialty Free thyroxine measurement Hypothalamo-Hypophyseal System business.industry Clinical Biochemistry Thyroid Gland Pituitary-Adrenal System 030209 endocrinology & metabolism General Medicine Free thyroxine Clinical Practice 03 medical and health sciences Thyroxine 0302 clinical medicine medicine Humans Triiodothyronine Intensive care medicine business Protein Binding |
| Zdroj: | Annals of clinical biochemistry. 25 |
| ISSN: | 0004-5632 |
| Popis: | Prime diagnostic importance has been postulated for the measurement of free thyroxine in human serum. During the past decade various innovative and routinely applicable techniques have been developed for its assay, and claims for their superior performance in clinical practice have subsequently been made. However, in our opinion, based on current literature concerning thyroxine metabolism together with basic information about the physicochemical characteristics that govern its intravascular distribution, it seems appropriate to indicate caution against overestimating the diagnostic sensitivity attributed to free thyroxine measurement irrespective of assay methodology and its conceptual elegance. |
| Databáze: | OpenAIRE |
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