A Prostate Cancer 'Nimbosus': Genomic Instability and SChLAP1 Dysregulation Underpin Aggression of Intraductal and Cribriform Subpathologies

Autor: Bernard Têtu, Jure Murgic, Anuradha Gopalan, Yves Fradet, Paul C. Boutros, Robert G. Bristow, Julie Livingstone, Melvin L.K. Chua, Louis Lacombe, Hélène Hovington, Alain Bergeron, Michèle Orain, Valérie Picard, Emilie Lalonde, Alice Meng, Osman Mahamud, Alan Dal Pra, Victor E. Reuter, Charlotte F. Kweldam, Neil Fleshner, Vinayak Bhandari, Melania Pintilie, Winnie Lo, Esther I. Verhoef, Agnes Marije Hoogland, Alejandro Berlin, Michael Fraser, Theodorus H. van der Kwast, Geert J.L.H. van Leenders, Junyan Zhang
Přispěvatelé: Pathology
Rok vydání: 2017
Předmět:
0301 basic medicine
Oncology
Male
medicine.medical_specialty
Pathology
Time Factors
Urology
In situ hybridization
Kaplan-Meier Estimate
Adenocarcinoma
Disease-Free Survival
Genomic Instability
Metastasis
03 medical and health sciences
Prostate cancer
0302 clinical medicine
SDG 3 - Good Health and Well-being
Risk Factors
Internal medicine
medicine
Carcinoma
Biomarkers
Tumor
Humans
Genetic Predisposition to Disease
Neoplasm Invasiveness
Copy-number variation
610 Medicine & health
Pathological
Netherlands
Proportional Hazards Models
Ontario
business.industry
Quebec
Prostatic Neoplasms
medicine.disease
Gene expression profiling
Gene Expression Regulation
Neoplastic
030104 developmental biology
Phenotype
Treatment Outcome
030220 oncology & carcinogenesis
Disease Progression
Tumor Hypoxia
New York City
RNA
Long Noncoding
business
Transcriptome
Zdroj: European Urology, 72(5), 665-674. Elsevier
ISSN: 1421-993X
0302-2838
Popis: BACKGROUND Intraductal carcinoma (IDC) and cribriform architecture (CA) represent unfavorable subpathologies in localized prostate cancer. We recently showed that IDC shares a clonal ancestry with the adjacent glandular adenocarcinoma. OBJECTIVE We investigated for the co-occurrence of "aggression" factors, genomic instability and hypoxia, and performed gene expression profiling of these tumors. DESIGN, SETTING, AND PARTICIPANTS A total of 1325 men were treated for localized prostate cancer from four academic institutions (University Health Network, CHU de Québec-Université Laval, Memorial Sloan Kettering Cancer Center [MSKCC], and Erasmus Medical Center). Pathological specimens were centrally reviewed. Gene copy number and expression, and intraprostatic oxygenation were assessed. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS IDC/CA was separately assessed for biochemical relapse risk in the Canadian and MSKCC cohorts. Both cohorts were pooled for analyses on metastasis. RESULTS AND LIMITATION Presence of IDC/CA independently predicted for increased risks of biochemical relapse (HRCanadian 2.17, p3-fold higher (p
Databáze: OpenAIRE
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