Positive Emotional Support in Premutation Carrier Mothers of Adolescents and Adults With Fragile X Syndrome: Gene by Environment Interactions

Autor: Leann Smith DaWalt, Sigan L. Hartley, Jinkuk Hong, Jan S. Greenberg, Marsha R. Mailick
Rok vydání: 2019
Předmět:
Adult
Male
Heterozygote
Cortisol awakening response
Emotional support
Adolescent
Health Status
Population
Mothers
Article
050105 experimental psychology
Fragile X Mental Retardation Protein
Young Adult
03 medical and health sciences
0302 clinical medicine
Trinucleotide Repeats
Arts and Humanities (miscellaneous)
Developmental and Educational Psychology
medicine
Humans
0501 psychology and cognitive sciences
education
Aged
education.field_of_study
Gene by environment
05 social sciences
Social Support
General Medicine
Genetic Status
Middle Aged
medicine.disease
FMR1
Fragile X syndrome
Psychiatry and Mental health
Neuropsychology and Physiological Psychology
Cgg repeat
Fragile X Syndrome
Pediatrics
Perinatology and Child Health
Female
Gene-Environment Interaction
Self Report
Neurology (clinical)
Psychology
030217 neurology & neurosurgery
Clinical psychology
Zdroj: American Journal on Intellectual and Developmental Disabilities. 124:411-426
ISSN: 1944-7558
1944-7515
DOI: 10.1352/1944-7558-124.5.411
Popis: We examined the benefit of emotional support on daily health in premutation carrier mothers of adolescents and adults with fragile X syndrome (n = 114), and whether this benefit was moderated by the mother's genetic status (FMR1 CGG repeat length). In an 8-day daily diary, maternal daily health was assessed subjectively through self-reported number of physical health symptoms and physiologically via cortisol awakening response. Multilevel lagged-day models indicated that premutation carrier mothers with midrange CGG repeats derived less health benefit from a day with high positive emotional support than those with lower or higher numbers of repeats within the premutation range. The data support the influence of both genetic and environmental influences on the health of this population.
Databáze: OpenAIRE
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