| Autor: |
Sepideh Borhan Dayani, Saeedeh Asgarbeik, Mojgan Asadi, Mahsa M. Amoli |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
J Diabetes Metab Disord |
| ISSN: |
2251-6581 |
| Popis: |
PURPOSE: Personal medicine is a new notion for individualizing treatment in the future. Studying pathogenic markers including genetic variants would be beneficial in better diagnosis and management of complex diseases such as diabetes and obesity. Adenosine deaminase (ADA) is a purine metabolic enzyme and modulates insulin activity in various tissues through several different mechanisms. Increased ADA activity is associated with decreased glucose uptake. A significant increase in serum deaminase activity has been reported in patients with T2DM and obesity. ADA gene polymorphisms seem to affect ADA enzymatic activity and a polymorphism at the position 4223 in the first intron of ADA gene (ADA 4223 A/C) has been previously associated with obesity. The aim of this study was to explore ADA gene 4223 A/C polymorphism and its association with obesity in patients with Type 2 diabetes. METHODS: Obese patients (N = 133: 64 diabetic +69 non-diabetic) with BMI ≥ 30 and subjects with BMI |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full text from SpringerLink