A novel delivery platform based on Bacteriophage MS2 virus-like particles
| Autor: | Yu Fu, Jinming Li |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cancer Research viruses Coat protein Article miR microRNA Epitope In vitro diagnostic Virus 03 medical and health sciences DC dendritic cell Bacteriophage MS2 Virology CCPD covalent coat protein dimer Animals Humans Levivirus Delivery platform biology Virus Assembly Gene Transfer Techniques Virion Virus-like particles equipment and supplies CP coat protein biology.organism_classification HPV human papilloma virus PAP prostatic acid phosphatase Therapeutic modalities In vitro 030104 developmental biology Infectious Diseases Capsid VLP virus-like particle FMDV foot-and-mouth disease virus Therapy GM-CSF granulocyte-macrophage colony-stimulating factor Vaccine |
| Zdroj: | Virus Research |
| ISSN: | 0168-1702 |
| DOI: | 10.1016/j.virusres.2015.08.022 |
| Popis: | Highlights • Here we reviewed Bacteriophage MS2 virus-like particles, including introduction to their structure, their potential as a delivery platform, and their expected use in medicine and other fields. • Bacteriophage MS2 virus-like particles represent the novel delivery platform. • Bacteriophage MS2 virus-like particles possess promising application prospect. Our objective here is to review the novel delivery platform based on Bacteriophage MS2 virus-like particles (VLPs), including introduction to their structure, their potential as a delivery platform, and their expected use in medicine and other fields. Bacteriophage MS2 VLPs are nanoparticles devoid of viral genetic material and can self-assemble from the coat protein into an icosahedral capsid. As a novel delivery platform, they possess numerous features that make them suitable and attractive for targeted delivery of RNAs or DNAs, epitope peptides, and drugs within the protein capsid. In short, as a novel delivery platform, MS2 VLPs are suitable for delivery of targeted agents and hold promise for use in diagnostics, vaccines, and therapeutic modalities. |
| Databáze: | OpenAIRE |
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