Therapy of Coagulation Factor VIII Autoantibodies with Long-term Extracorporeal Protein A Adsorption and Immunosuppression
| Autor: | Ralf Grossmann, Dieter Wiebecke, Franz Keller, Behrouz Mansouri Taleghani |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Cyclophosphamide medicine.medical_treatment Immunology Gastroenterology Extracorporeal Plasma flow Internal medicine medicine Humans Staphylococcal Protein A Immunosorbent Techniques Autoantibodies Factor VIII biology business.industry Autoantibody Immunosuppression Hematology Middle Aged Surgery Titer Coagulation biology.protein Female business Protein A Immunosuppressive Agents medicine.drug |
| Zdroj: | Transfusion Science. 19:39-42 |
| ISSN: | 0955-3886 |
| Popis: | Acquired factor VIII (FVIII) inhibitors in non-haemophiliacs may pose serious treatment problems.For IgG-adsorptions we utilized an automated plasma separation device and a plasma flow monitor.A 63-year old woman showed life-threatening bleeding because of an inhibitor. After stabilization by porcine FVIII three cycles of a modified Malmoe treatment protocol were applied, followed by long-term cyclophosphamide p.o. and weekly IgG-adsorptions. Within twelve months the patient exhibited a complete remission. A 54-year old man presented a comparable history. Because of a good response after the first cycle he was subsequently switched to the long-term therapy. Up to now (7 months) FVIII activities and inhibitor titers remained stable (10-20% rsp.3 BU/ml). In both cases no FVIII substitution therapy was necessary.A modified Malmoe protocol combined with long-term cyclophosphamide p.o. and weekly IgG-adsorptions seems to be an efficient, safe and cost-effective regimen for non-haemophiliacs with FVIII inhibitors. |
| Databáze: | OpenAIRE |
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