Inter- and intra-observer reproducibility of ADC measurements in esophageal carcinoma primary tumors
| Autor: | Shujun Dai, Zhenfu Fu, Yuezhen Wang, Zhimin Ye, Tieming Xie, Jun Fang, Fangzheng Wang, Kai Li, Zhun Wang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Treatment response medicine.medical_treatment 030218 nuclear medicine & medical imaging esophageal carcinoma 03 medical and health sciences 0302 clinical medicine Radiation oncology Carcinoma Medicine reproducibility Reproducibility business.industry Cancer medicine.disease Primary tumor Intra observer Surgery body regions Radiation therapy diffuse weighted imaging Oncology 030220 oncology & carcinogenesis business Nuclear medicine apparent diffused coefficient Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.21639 |
| Popis: | // Zhimin Ye 1, * , Jun Fang 1, * , Shujun Dai 2 , Tieming Xie 3 , Fangzheng Wang 1 , Zhun Wang 1 , Kai Li 3 , Zhenfu Fu 1 and Yuezhen Wang 1 1 Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, China 2 Department of Intensive Care Unit, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China 3 Department of Radiology, Zhejiang Cancer Hospital, Hangzhou, China * These authors are considered as co-first authors Correspondence to: Zhun Wang, email: wangzhun007@hotmail.com Zhenfu Fu, email: fuzf1000@163.com Keywords: esophageal carcinoma, diffuse weighted imaging, apparent diffused coefficient, reproducibility Received: June 16, 2017 Accepted: August 17, 2017 Published: October 06, 2017 ABSTRACT The apparent diffuse coefficient (ADC) may correlate with the treatment response to chemotherapy/radiotherapy in solid tumors. Our aim was to determine the inter- and intra-observer reproducibility of ADC measurements in primary esophageal squamous cell carcinoma (ESCC). ADCs were blindly measured in 31 patients diagnosed with ESCC by two observers before treatment (pre-ADC) and after 5 th fraction radiotherapy (intra-ADC) twice with a 2-week interval. The mean pre-ADC of primary tumors was 1.25±0.22 and 1.27±0.23 (in 10 −3 mm 2 /s) from observer A for measurements 1 and 2, respectively, and the intra-observer measurements were -0.02 bias vs. -0.13-0.09 limits of agreement. From observer B, the mean pre-ADC varied between 1.25±0.23 and 1.27±0.23 (in 10 −3 mm 2 /s) for measurements 1 and 2, respectively, and intra-observer measurements were -0.02 bias vs. -0.17~0.16 limits of agreement. The mean pre-ADC of primary tumors was 1.26±0.24 (in 10 −3 mm 2 /s) from observers A and B, and inter-observer measurements were 0.01 bias vs. -0.09-0.09 limits of agreement, revealing a low inter-observer variance. Similar measurements of the intra-SD parameters showed that the pre- and intra-ADC of primary tumors differed significantly. Thus ADC measurements may have sufficient inter-observer and intra-observer reproducibility to measure primary tumor responses to treatment, and the ADCs before and during treatment differed. |
| Databáze: | OpenAIRE |
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