Mechanisms Underlying Connexin Hemichannel Activation in Disease

Autor: Raf Van Campenhout, Timo W.M. De Groof, Nick Devoogdt, Ana Rita Coelho Gomes, Serge Muyldermans, Mathieu Vinken
Přispěvatelé: Pharmaceutical and Pharmacological Sciences, Faculty of Medicine and Pharmacy, Experimental in vitro toxicology and dermato-cosmetology, Supporting clinical sciences, Vriendenkring VUB, Medical Imaging, Translational Imaging Research Alliance, Liver Connexin and Pannexin Research Group, Connexin Signalling Research Group
Rok vydání: 2021
Předmět:
Connexin
Review
Connexins
lcsh:Chemistry
0302 clinical medicine
Cytosol
Homeostasis
Phosphorylation
lcsh:QH301-705.5
Spectroscopy
0303 health sciences
Cell Death
Chemistry
Gap junction
Gap Junctions
General Medicine
Hydrogen-Ion Concentration
3. Good health
Computer Science Applications
Cell biology
medicine.symptom
Intracellular
Programmed cell death
mechanism
Inflammation
Catalysis
Connexon
Inorganic Chemistry
03 medical and health sciences
medicine
Extracellular
otorhinolaryngologic diseases
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
030304 developmental biology
Organic Chemistry
Cell Membrane
Pathogen-Associated Molecular Pattern Molecules
lcsh:Biology (General)
lcsh:QD1-999
Connexin 43
pathology
sense organs
Stress
Mechanical
Peptides
connexin hemichannel
030217 neurology & neurosurgery
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 3503, p 3503 (2021)
ISSN: 1422-0067
Popis: Gap junctions and connexin hemichannels mediate intercellular and extracellular communication, respectively. While gap junctions are seen as the “good guys” by controlling homeostasis, connexin hemichannels are considered as the “bad guys”, as their activation is associated with the onset and dissemination of disease. Open connexin hemichannels indeed mediate the transport of messengers between the cytosol and extracellular environment and, by doing so, fuel inflammation and cell death in a plethora of diseases. The present mini-review discusses the mechanisms involved in the activation of connexin hemichannels during pathology.
Databáze: OpenAIRE
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