A comprehensive analysis of the genomic organization, expression and phylogeny of immunoglobulin light chain genes in pigeon (Columba livia)
| Autor: | Tian Huang, Gengsheng Cao, Zheya Sheng, Xiaoxing Guan, Linyun Guo |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Immunology Gene Expression Locus (genetics) Biology Genome Avian Proteins Evolution Molecular 03 medical and health sciences Phylogenetics Gene Duplication Sequence Homology Nucleic Acid Gene duplication Animals Columbidae Gene Phylogeny Genomic organization Base Sequence Phylogenetic tree Genetic Variation biology.organism_classification V(D)J Recombination 030104 developmental biology Evolutionary biology Immunoglobulin Light Chains Genes Immunoglobulin Light Chain Neoaves Developmental Biology |
| Zdroj: | Developmental & Comparative Immunology. 89:66-72 |
| ISSN: | 0145-305X |
| Popis: | Previous studies on immunoglobulin light chain (IgL) genes in avian species are limited to Galloanseres, and few studies have investigated IgL genes in Neoaves, which includes most living birds. Based on published genome data, we demonstrate that the pigeon ( Columba livia ) IgL locus spans approximately 24 kb of DNA and contains twenty Vλ segments located upstream of a single pair of Jλ-Cλ. Among the identified Vλ gene segments, four segments are structurally intact and all four segments are able to recombine with Jλ. Moreover, the four functional Vλ segments are preferentially utilized in VλJλ recombination. Phylogenetic analysis suggests that the presence of the four functional Vλ segments in pigeon was likely generated by gene duplication that occurred after the divergence of pigeon and other birds. Our study provides insight into IgL gene evolution and evolutionary diversity of Ig genes in birds. |
| Databáze: | OpenAIRE |
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