Transient reduction of spontaneous neuronal network activity by sublethal amyloid β (1–42) peptide concentrations
| Autor: | Mario Siebler, Susanne Aileen Funke, Jessica Opatz, Dieter Willbold, Christian Lange-Asschenfeldt, Philipp Görtz |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Neurology Amyloid Amyloid β Cell Culture Techniques Action Potentials Peptide Biology medicine Biological neural network Animals Biological Psychiatry Cerebral Cortex Neurons chemistry.chemical_classification Amyloid beta-Peptides Neurodegeneration medicine.disease Peptide Fragments Pathophysiology Rats Electrophysiology Psychiatry and Mental health chemistry Burst rate Neurology (clinical) Nerve Net Microelectrodes Neuroscience |
| Zdroj: | Journal of Neural Transmission. 116:351-355 |
| ISSN: | 1435-1463 0300-9564 |
| DOI: | 10.1007/s00702-009-0188-y |
| Popis: | Soluble amyloid beta(1-42) (A beta(1-42)) peptide has recently been assigned a key role in early Alzheimer's disease (AD) pathophysiology accounting for synaptic dysfunction before amyloid plaque formation and neurodegeneration can occur. Following sublethal A beta(1-42) administration, we observed an acute but transient reduction of the spike and burst rate of spontaneously active cortical networks cultured on microelectrode arrays. This simple experimental system appears suitable for future long-term pharmacological and genetic studies of A beta(1-42) signaling, thus providing a valuable new tool in AD research. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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