Association of liver enzymes levels with fasting plasma glucose levels in Southern China: a cross-sectional study
| Autor: | Dong-Hui Guo, Yong-Ping Jin, Hui-Yan Xu, Xiao Xiao Wang, Song-Tao Tang, Ling-Ling Huang, Pei-Xi Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
Male China endocrine system diseases Cross-sectional study Physiology 030209 endocrinology & metabolism Overweight Logistic regression Body Mass Index 03 medical and health sciences 0302 clinical medicine Liver enzyme Southern China medicine fasting plasma glucose cross-sectional study Humans 030212 general & internal medicine Aspartate Aminotransferases Obesity Original Research Aged biology business.industry nutritional and metabolic diseases Alanine Transaminase General Medicine Glucose Tolerance Test Middle Aged medicine.disease liver enzymes Diabetes and Endocrinology Cross-Sectional Studies Logistic Models Alanine transaminase Liver Multivariate Analysis biology.protein Female medicine.symptom Underweight business Body mass index |
| Zdroj: | BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | ObjectiveAccording to several studies, liver enzymes levels are associated with fasting plasma glucose (FPG) levels. However, the association stratified by body mass index (BMI) remains to be elucidated, especially in Southern China. Therefore, the aim of this study was to investigate the correlation between liver enzymes levels and FPG levels stratified by BMI in Southern China.DesignCross-sectional study.Participants and setting3056 individuals participated in real-time interviews and blood tests in Southern China. Participants were divided into three groups (underweight, normal weight and overweight or obesity) based on BMI cut-offs.Main outcome measuredPartial correlation analysis was performed to investigate the relationship between FPG levels and liver tests. Multivariate logistic regression analyses were applied to calculate the adjusted ORs for FPG levels based on liver enzymes levels.ResultsThere was no association between liver enzymes and FPG either in the underweight group or in the normal weight group; however, a significant correlation was observed in the overweight or obesity group (alanine transaminase (ALT), pConclusionsThe association of liver enzymes levels with FPG levels differed based on different BMI cut-offs. ALT levels were significantly positively associated with FPG levels in the overweight or obesity group, but not in the other two groups; AST levels were not associated with FPG levels in any group. |
| Databáze: | OpenAIRE |
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