Near-infrared measurements of brain oxygenation in stroke
| Autor: | Andrew M. Demchuk, Runze Yang, Jeff Dunn, Vivek K. Nambiar, François Moreau |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Stroke patient Neuroscience (miscellaneous) 01 natural sciences 010309 optics 03 medical and health sciences 0302 clinical medicine Text mining Neuroimaging Internal medicine Special Section on Clinical Near-Infrared Spectroscopy and Imaging of the Brain 0103 physical sciences Healthy volunteers Medicine Radiology Nuclear Medicine and imaging cardiovascular diseases Stroke Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Oxygenation medicine.disease Surgery Positron emission tomography Cardiology Monitoring tool business 030217 neurology & neurosurgery |
| Zdroj: | Neurophotonics. 3(3) |
| ISSN: | 2329-423X |
| Popis: | We investigated the feasibility of using frequency-domain near-infrared spectroscopy (fdNIRS) to study brain oxygenation in the first few hours of stroke onset. The OxiplexTS(®) fdNIRS system was used in this study. Using a standard probing protocol based on surface landmarks, we measured brain tHb and [Formula: see text] in healthy volunteers, cadavers, and acute stroke patients within 9 h of stroke onset and 3 days later. We obtained measurements from 11 controls, 5 cadavers, and 5 acute stroke patients. [Formula: see text] values were significantly lower in cadavers compared to the controls and stroke patients. Each stroke patient had at least one area with reduced [Formula: see text] on the stroke side compared to the contralateral side. The evolution of tHb and [Formula: see text] at 3 days differed depending on whether a large infarct occurred. This study shows the proof of principle that quantified measurements of brain oxygenation using NIRS could be used in the hectic environment of acute stroke management. It also highlights the current technical limitations and future challenges in the development of this unique bedside monitoring tool for stroke. |
| Databáze: | OpenAIRE |
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