Risk factors for anastomotic recurrence after primary ileocaecal resection in Crohn’s disease
| Autor: | Monika Carpelan-Holmström, Ilona Keränen, Anna Lepistö, Gisele Aaltonen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Ileocaecal resection medicine.medical_specialty Adolescent Disease Anastomosis Resection Young Adult 03 medical and health sciences 0302 clinical medicine Crohn Disease Adrenal Cortex Hormones Ileum Recurrence Risk Factors Surgical Stapling Humans Medicine Postoperative Period Young adult Cecum Emergency Treatment Aged Retrospective Studies Aged 80 and over Crohn's disease Hepatology business.industry Anastomosis Surgical Gastroenterology Retrospective cohort study Middle Aged medicine.disease digestive system diseases 3. Good health Surgery Natural history 030220 oncology & carcinogenesis Female 030211 gastroenterology & hepatology business Follow-Up Studies |
| Zdroj: | European Journal of Gastroenterology & Hepatology. 30:1143-1147 |
| ISSN: | 0954-691X |
| DOI: | 10.1097/meg.0000000000001206 |
| Popis: | Ileocaecal resection is the most common operation performed in Crohn's disease. Our study aimed to identify the risk factors for anastomotic recurrence following primary ileocaecal resection.We retrospectively analysed data from all Crohn's disease surgical patients in a single colorectal unit between 2006 and 2016, including all patients who underwent primary ileocaecal resection. We defined anastomotic recurrence as the postoperative need for endoscopic dilatation of the ileocolic anastomosis or neoterminal ileal resection, and used Cox regression to determine the risk factors for such recurrence.In total, 101 patients underwent primary ileocaecal resection during the study period. Nine (8.9%) patients were excluded because of follow-up less than 1 year and 12 (13.0%) patients had anastomotic recurrence. The median follow-up was 4.7 (1.3-10.8) years. At 3 years, 93.1% of patients required no neoterminal ileal resection or dilatation of the ileocolic anastomosis. Urgent primary ileocaecal resection [hazard ratio (HR)=4.98, 95% confidence interval (CI)=1.45-17.11, P=0.011], stapled anastomosis (HR=20.34, 95% CI=5.06-81.77, P0.001) and need for postoperative corticosteroid treatment after the primary ileocaecal resection (HR=3.58, 95% CI=1.03-12.40, P=0.044) emerged as significant risk factors for anastomotic recurrence.Urgent surgery and postoperative corticosteroid need represented risk factors for anastomotic recurrence. Hand-sewn anastomosis with an opening of the bowel's antimesenteric border seems to be a safe choice for ileocaecal resection. |
| Databáze: | OpenAIRE |
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