Are Zika virus cross-reactive antibodies against aquaporin-4 associated to Neuromyelitis Optica Spectrum Disorder?
| Autor: | Rafael Dhalia, Maria Notomi Sato, Roberto D. Lins, Isabelle F. T. Viana, Franciane Mouradian Emidio Teixeira, Bruno H.S. Leite, Catarina Maria Cataldi Sabino de Araújo, Anna Cláudia Calvielli Castelo Branco, Danilo F. Coêlho, João P.M. Brainer-Lima, Ernesto T. A. Marques |
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| Rok vydání: | 2021 |
| Předmět: |
Immunology
Inflammation Cross Reactions Viral Nonstructural Proteins Antibodies Viral Virus Replication Zika virus Epitopes Mice medicine Immunology and Allergy Animals Humans Autoantibodies Aquaporin 4 Neuromyelitis optica biology business.industry Zika Virus Infection Molecular Mimicry Neuromyelitis Optica Optic Nerve Zika Virus biology.organism_classification medicine.disease Phenotype Virology Mice Inbred C57BL Neurology Viral replication Immunoglobulin G Optic nerve biology.protein sense organs Neurology (clinical) medicine.symptom Antibody business |
| Zdroj: | Journal of neuroimmunology. 360 |
| ISSN: | 1872-8421 |
| Popis: | Zika virus (ZIKV) infection has been associated with the development of Neuromyelitis Optica Spectrum Disorder (NMOSD). ZIKV-induced antibodies that putatively cross-react to aquaporin-4 (AQP4) protein are suggested to cause inflammation of the optic nerve. A region of similarity between AQP4 and the ZIKV NS2B protein was identified. Our data showed that ZIKV-associated NMOSD patients develop anti-AQP4 antibodies, but not anti-ZIKV NS2B antibodies, revealing that cross-reacting antibodies are not the underlying cause of this phenotype. ZIKV infection in mice showed persistent viral replication in the eye tissue, suggesting that NMOSD symptoms are consequence of viral infection of the optic nerve cells. |
| Databáze: | OpenAIRE |
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