Association between STR -794 CATT5-8 and SNP -173 G/C polymorphisms in the MIF gene and Lepromatous Leprosy in Mestizo patients of western Mexico
Autor: | Mary Fafutis-Morris, Anabell Alvarado-Navarro, Marco Alonso Martinez-Guzman, J.F. Muñoz-Valle, Ana Laura Pereira-Suárez |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Adult Male Genotype Immunology Biology Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Gene Frequency medicine Immunology and Allergy SNP Humans Genetic Predisposition to Disease Allele Promoter Regions Genetic Genotyping Mycobacterium leprae Macrophage Migration-Inhibitory Factors Mexico Aged Lepromatous leprosy General Medicine Middle Aged medicine.disease biology.organism_classification Intramolecular Oxidoreductases Leprosy Lepromatous 030104 developmental biology 030220 oncology & carcinogenesis Macrophage migration inhibitory factor Female Leprosy Restriction fragment length polymorphism Microsatellite Repeats |
Zdroj: | Human immunology. 77(10) |
ISSN: | 1879-1166 |
Popis: | Lepromatous Leprosy (LL) is the most common presentation of leprosy in Mexico. LL patients are unable to activate an effective inflammatory response against Mycobacterium leprae probably due to the genetics of the host. Macrophage Migration Inhibitory Factor (MIF) is important to trigger inflammation processes. Two polymorphisms have been reported for human MIF: STR -794 CATT5-8 and SNP -173 G/C. 7-8 CATT repeats at -794 and the C allele at -173 increase the expression of MIF. We aim to determine the association between the polymorphisms in MIF gene and LL. We carried a case and controls study with 100 Mexican LL patients and 100 healthy subjects (HS). PCR was used for genotyping of STR -794 CATT5-8 polymorphism and PCR-RFLP for -173 G/C. We found that LL patients possess high -794 CATT repeats (47.1%) more often than HS (32.7%). In conclusion, a MIF polymorphism is associated with susceptibility to LL in Western Mexican population. |
Databáze: | OpenAIRE |
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