Antifungal and wound healing promotive compounds from the resins of Dracaena cochinchinensis
| Autor: | Yong-Ming Yan, Shu-Min Zheng, Dai-Wei Wang, Ya-Bin Jiao, Feng Wang, Tian-Chang He, Yong-Xian Cheng |
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| Rok vydání: | 2021 |
| Předmět: |
China
Antifungal Agents Phytochemicals 01 natural sciences Drug Discovery Human Umbilical Vein Endothelial Cells Magnaporthe grisea HaCaT Cells Humans Glycosides Dracaena Botrytis cinerea Pharmacology Tube formation chemistry.chemical_classification Flavonoids Penicillium digitatum Wound Healing biology Traditional medicine Molecular Structure 010405 organic chemistry Plant Extracts Sclerotinia sclerotiorum Glycoside General Medicine biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry HaCaT chemistry Wound healing Resins Plant |
| Zdroj: | Fitoterapia. 151 |
| ISSN: | 1873-6971 |
| Popis: | Five new compounds (xuejieins A–E), including three new phenolic glycosides (1, 2, and 5) and two new flavonoids (10 and 11), together with six known compounds were isolated from the resins of Dracaena cochinchinensis (Chinese dragon's blood). The structures of the new compounds were confirmed by extensive spectroscopic methods and electronic circular dichroism (ECD) data analysis. Especially, the absolute configurations of the sugar moieties in compounds 1, 2, and 5 were clarified by GC analysis after acid hydrolysis. All isolated compounds have been tested for antifungal and wound healing promoting activities, The results showed that compound 9 shows significant antifungal activities against Botrytis cinerea, Magnaporthe grisea, Penicillium digitatum, and Sclerotinia sclerotiorum. In addition, compound 4 could significantly stimulate human keratinocytes (HaCAT) proliferation, mobility, and human umbilical vein vascular endothelial cells (HUVECs) tube formation at 40 μM. |
| Databáze: | OpenAIRE |
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