Enantioselective Construction of C3-Multifunctionalization α-Hydroxy-β-amino Pyridines via α-Pyridyl Diazoacetate, Water, and Imines for Drug Hunting

Autor:	Jian Xue, Zhengli Luo, Jisheng Huang, Yaqi Deng, Suzhen Dong, Shunying Liu
Rok vydání:	2022
Předmět:	Molecular Structure Pyridines Organic Chemistry Water Hunting Stereoisomerism Imines Physical and Theoretical Chemistry Biochemistry
Zdroj:	Organic Letters. 24:9502-9507
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.2c03987
Popis:	An asymmetric catalytic approach for the construction of C3-multifunctionalization α-hydroxy-β-amino pyridines has been reported. The products can be accessed by the modulation of two chiral catalysts independently in high yield and with good enantioselectivity. The method features mild reaction conditions and an excellent functional group tolerance. Biological activity analysis shows that the resulting products have a selective antiosteosarcoma activity on 143B cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf81291eb47dab20059739adef0f860 https://doi.org/10.1021/acs.orglett.2c03987 Zobrazit plný text záznamu