Criteria for eligibility to cisplatin in the curative treatment of head and neck cancer: Consensus opinion from a panel of experts
| Autor: | Thiago Bueno Oliveira, Ana F. Castro, Ulisses Ribaldo Nicolau, Gilberto de Castro, Andrey Soares, Pedro De Marchi, Aline Lauda Freitas Chaves, Rodrigo S.C. Guindalini, Gustavo V. Alves, Paulo A.R. Mora, Fernando L. Dias |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Consensus medicine.medical_treatment MEDLINE Antineoplastic Agents 03 medical and health sciences 0302 clinical medicine Pharmacotherapy Epidemiology Humans Medicine Intensive care medicine Expert Testimony Cisplatin Modalities Cetuximab business.industry Patient Selection Head and neck cancer Hematology medicine.disease Radiation therapy 030104 developmental biology Oncology Head and Neck Neoplasms 030220 oncology & carcinogenesis Carcinoma Squamous Cell business medicine.drug |
| Zdroj: | Critical Reviews in Oncology/Hematology. 131:30-34 |
| ISSN: | 1040-8428 |
| Popis: | Squamous-cell carcinoma of the head and neck (SCCHN) is an important problem in Brazil, where epidemiological and socioeconomic features often create barriers to the implementation of combined modalities with curative potential. Cisplatin improves the efficacy of radiotherapy in the adjuvant treatment of localized SCCHN and in the definitive therapy of locally advanced disease. However, the addition of high-dose cisplatin to radiotherapy increases treatment toxicity and is not always warranted. A panel of experts convened in Sao Paulo, Brazil, for discussions and recommendations regarding the use of high-dose cisplatin in combination with radiotherapy in SCCHN. In addition to discussing their professional experience, panel members used the current literature to provide evidence-based, practical recommendations regarding sociodemographic or medical criteria that may preclude safe administration of cisplatin. It is hoped that the application of these recommendations in clinical practice may improve therapeutic results in Brazil and other countries with similar health-care environments. |
| Databáze: | OpenAIRE |
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