First trimester prediction of gestational diabetes mellitus using plasma biomarkers: a case-control study

Autor: Jorge Cortez, Daniela Albers, Pía Venegas, Manuel Schepeler, Sebastian E. Illanes, Jaime Roa, Gregory E. Rice, Paula Correa, Max Monckeberg, Eduardo Osorio, Yasna Palmeiro
Rok vydání: 2018
Předmět:
Adult
Blood Glucose
medicine.medical_specialty
Very low-density lipoprotein
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
High-density lipoprotein
Predictive Value of Tests
Pregnancy
Sex Hormone-Binding Globulin
Internal medicine
medicine
Humans
Insulin
Aspartate Aminotransferases
030212 general & internal medicine
Chile
Triglycerides
030219 obstetrics & reproductive medicine
Adiponectin
business.industry
Area under the curve
Reproducibility of Results
Obstetrics and Gynecology
Alanine Transaminase
gamma-Glutamyltransferase
medicine.disease
Gestational diabetes
Diabetes
Gestational
Pregnancy Trimester
First
Cholesterol
Early Diagnosis
Endocrinology
ROC Curve
chemistry
Case-Control Studies
Tissue Plasminogen Activator
Pediatrics
Perinatology and Child Health
Homeostatic model assessment
Female
Glycated hemoglobin
business
Biomarkers
Zdroj: Journal of Perinatal Medicine. 47:161-168
ISSN: 1619-3997
0300-5577
Popis: Objectives To evaluate the first trimester maternal biomarkers for early pregnancy prediction of gestational diabetes mellitus (GDM). Methods The study was a case-control study of healthy women with singleton pregnancies at the first trimester carried out at the Obstetrics and Gynecology Unit, Clinica Davila, Santiago, Chile. After obtaining informed consent, peripheral blood samples of pregnant women under 14 weeks of gestation were collected. At 24–28 weeks of pregnancy, women were classified as GDM (n=16) or controls (n=80) based on the results of a 75-g oral glucose tolerance test (OGTT). In all women, we measured concentrations of fasting blood glucose, insulin, glycated hemoglobin, uric acid, cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), triglycerides, aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyl transpeptidase (GGT), alkaline phosphatase (AP), sex hormone-binding globulin (SHBG), adiponectin, tissue plasminogen activator (t-PA), leptin and placental growth factor (PGF). Results The GDM group displayed an increased median concentration of cholesterol (P=0.04), triglycerides (P=0.003), insulin (P=0.003), t-PA (P=0.0088) and homeostatic model assessment (HOMA) (P=0.003) and an increased mean concentration of LDL (P=0.009) when compared to the control group. The receiver operating characteristic (ROC) curve for significant variables achieved an area under the curve (AUC) of 0.870, a sensitivity of 81.4% and a specificity of 80.0%. The OGTT was positive for GDM according to the IADPSG (International Diabetes in Pregnancy Study Group) criteria. Conclusion Women who subsequently developed GDM showed higher levels of blood-borne biomarkers during the first trimester, compared to women who did not develop GDM. These data warrant validation in a larger cohort.
Databáze: OpenAIRE
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