Levels of beta-trace protein in optic disc pit with macular detachment

Autor:	Sven Crafoord, Torbjörn K. Nilsson, Karim Makdoumi
Rok vydání:	2017
Předmět:	Adult Male medicine.medical_specialty BETA-TRACE Adolescent genetic structures Optic Disk beta-trace protein Endotamponade beta trace Beta-Trace Protein Young Adult 03 medical and health sciences 0302 clinical medicine Nephelometry and Turbidimetry Vitrectomy Ophthalmology Optic Nerve Diseases medicine Humans Macula Lutea Cerebrospinal Fluid Chemistry β trace protein Subretinal Fluid Retinal Detachment Original Articles General Medicine Middle Aged Lipocalins eye diseases Macular detachment Intramolecular Oxidoreductases medicine.anatomical_structure β‐trace protein beta‐trace protein Oftalmologi 030221 ophthalmology & optometry optic disc pit Original Article Female sense organs Subretinal fluid Biomarkers Tomography Optical Coherence 030217 neurology & neurosurgery Optic disc
Zdroj:	Acta Ophthalmologica
ISSN:	1755-375X
DOI:	10.1111/aos.13527
Popis:	Background To report beta‐trace protein (β TP) levels in the subretinal fluid (SRF) of four patients with a macular detachment associated with optic disc pit (ODP). Methods Four patients with a serous retinal detachment involving the macula was operated by pars plana vitrectomy (PPV) with C2F6 gas tamponade and peeling of internal limiting membrane (ILM). Patients with a follow‐up period exceeding one year postoperatively were included in the study. The SRF was drained using a fine cannula without laser photocoagulation, and the samples were analysed using particle‐enhancing nephelometry. The levels of β TP were compared to 20 routine cerebrospinal fluid (CSF) samples. Results In four of the five samples from SRF had relatively low β TP levels, with a mean concentration of 6.6 mg/l (range 2.0 to 23.1 mg/l) compared to 16.0 mg/l (range 6.3‐26.8 mg/l) in CSF. The only SRF sample within the range corresponding to normal CSF was the first sample from patient 4, and the analysis of the renewed aspirate during the second operation was 2.8 mg/l. Postoperatively, the regression of SRF was slow, but regression of SRF in the foveal region took place in all cases; however, visual acuity (VA) was improved in only half of the patients. Conclusion The results from the analysed SRF regarding β TP concentration in these patients indicate that the SRF in ODP is not identical to CSF, as the concentrations of β TP differ.
Databáze:	OpenAIRE
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