High Aerobic Capacity Mitigates Changes in the Plasma Metabolomic Profile Associated with Aging
| Autor: | Oluyemi S. Falegan, Dustin S. Hittel, Steven L. Britton, Hans J. Vogel, Lauren G. Koch, Russell T. Hepple, Jane Shearer |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Aging medicine.medical_specialty Magnetic Resonance Spectroscopy Rat model Biology Biochemistry Running 03 medical and health sciences Oxygen Consumption Metabolomics Risk Factors Internal medicine medicine Metabolome Animals Risk factor Aerobic capacity Myocardium VO2 max General Chemistry Metabolism Rats 030104 developmental biology Endocrinology Disease risk |
| Zdroj: | Journal of Proteome Research. 16:798-805 |
| ISSN: | 1535-3907 1535-3893 |
| DOI: | 10.1021/acs.jproteome.6b00796 |
| Popis: | Advancing age is associated with declines in maximal oxygen consumption. Declines in aerobic capacity not only contribute to the aging process but also are an independent risk factor for morbidity, cardiovascular disease, and all-cause mortality. Although statistically convincing, the relationships between aerobic capacity, aging, and disease risk remain largely unresolved. To this end, we employed sensitive, system-based metabolomics approach to determine whether enhanced aerobic capacity could mitigate some of the changes seen in the plasma metabolomic profile associated with aging. Metabolomic profiles of plasma samples obtained from young (13 month) and old (26 month) rats bred for low (LCR) or high (HCR) running capacity using proton nuclear magnetic resonance spectroscopy (1H NMR) were examined. Results demonstrated strong profile separation in old and low aerobic capacity rats, whereas young and high aerobic capacity rat models were less predictive. Significantly differential metabolites between th... |
| Databáze: | OpenAIRE |
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