Association of regional gray matter volume loss and progression of white matter lesions in multiple sclerosis — A longitudinal voxel-based morphometry study
| Autor: | Yvonne Naegelin, Ludwig Kappos, Paul M. Matthews, Stefan Traud, Achim Gass, Ernst-Wilhelm Radue, Nicole Mueller-Lenke, Hanspeter Egger, Sebastian Winklhofer, Thomas E. Nichols, Stefan Borgwardt, Pascal Kuster, Kerstin Bendfeldt |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Multiple Sclerosis Cognitive Neuroscience Precuneus Nerve Fibers Myelinated Lesion White matter Imaging Three-Dimensional Image Interpretation Computer-Assisted medicine Humans Longitudinal Studies Neurons Temporal cortex Multiple sclerosis Voxel-based morphometry medicine.disease Magnetic Resonance Imaging Hyperintensity medicine.anatomical_structure Neurology Posterior cingulate Female medicine.symptom Psychology |
| Zdroj: | NeuroImage. 45:60-67 |
| ISSN: | 1053-8119 |
| DOI: | 10.1016/j.neuroimage.2008.10.006 |
| Popis: | Previous studies have established regional gray matter (GM) volume loss in multiple sclerosis (MS) but the relationship between development of white matter (WM) lesions and changes of regional GM volumes is unclear. The present study addresses this issue by means of voxel-based morphometry (VBM). T1-weighted three-dimensional magnetic resonance imaging (MRI) data from MS patients followed up for 12 months were analyzed using VBM. An analysis of covariance model assessed with cluster size inference (all corrected for multiple comparisons, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect