The risk of osteonecrosis of the jaw and adverse outcomes in patients using antiresorptive drugs undergoing orthodontic treatment: A systematic review
| Autor: | Julian Woolley, Mônica Diuana Calasans-Maia, Iryna Kocherhina, José de Albuquerque Calasans-Maia, Oladapo Akintola, Julian Yates, Roberto Sacco |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty MEDLINE Orthodontics CINAHL Review Article MRONJ Tooth mobility 03 medical and health sciences 0302 clinical medicine Pharmacotherapy Internal medicine medicine Clinical significance lcsh:Social sciences (General) Adverse effect Prospective cohort study lcsh:Science (General) Multidisciplinary business.industry Osteonecrosis medicine.disease 030104 developmental biology Antiresorptive drugs Tooth movement lcsh:H1-99 Orthodontic treatment business Osteonecrosis of the jaw 030217 neurology & neurosurgery lcsh:Q1-390 |
| Zdroj: | Heliyon, Vol 7, Iss 1, Pp e05914-(2021) Heliyon Yates, J 2021, ' The risk of osteonecrosis of the jaw and adverse outcomes in patients using antiresorptive drugs undergoing orthodontic treatment: A systematic review ', Heliyon . https://doi.org/10.1016/j.heliyon.2021.e05914 |
| ISSN: | 2405-8440 |
| DOI: | 10.1016/j.heliyon.2021.e05914 |
| Popis: | Objectives Medication-related osteonecrosis of the jaw (MRONJ) is rare. It is a serious adverse effect of certain drugs, of which bisphosphonates (BPs) are the most widely known. The aim of this systematic review was to analyze all published evidence for the reported adverse outcomes as a result of orthodontic treatment in patients undergoing antiresorptive therapy. Data All types of studies involving patients undergoing orthodontic treatment and treated with antiresorptive drugs were considered. A meta-analysis was not conducted due to the high amount of variability and heterogeneity in the reporting and presentation of data among the studies meeting the inclusion criteria. Sources A systematic search was performed using 4 databases (PubMed, MEDLINE, EMBASE and CINAHL). Study selection Seven studies matched the inclusion criteria for this review, reporting a total of 29 patients. MRONJ was only reported in 1 patient. The adverse outcomes following orthodontic treatment included difficulty achieving root parallelism (n = 4), difficulty achieving complete space closure (n = 3), exaggerated tooth mobility post-debond (n = 2), increased duration of orthodontic treatment beyond expected completion (n = 1), sclerotic alveolar bone changes seen on post-op radiographic images (n = 2), and an increased amount of root resorption (n = 1). Conclusions The high amount of heterogeneity and limited evidence precluded a valid interpretation and analysis of the results through pooling of data. Additional data with sufficient quality, a reduction of bias, and a greater prospective cohort of patients is crucial to assess adverse effects, mechanisms of action, and associated risk factors in at-risk patients. Clinical significance Based on the limited evidence available in the literature, it is unclear whether orthodontic treatment alone can precipitate MRONJ. However, antiresorptive drug therapy may be associated with a sub-optimal treatment outcome. Orthodontic treatment, Orthodontics, Osteonecrosis, MRONJ, Tooth movement, Antiresorptive drugs. |
| Databáze: | OpenAIRE |
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