Permeability of Intestinal and Blood—Tissue Barriers in Rats for Evans Blue Dye under Conditions of Acute Intoxication with Cyclophosphamide
| Autor: | Ju. Ju. Ivnitsky, T V Schäfer, Vladimir L. Rejniuk |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Cyclophosphamide Ileum Pharmacology Kidney General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals Lung Evans Blue business.industry Brain Acute intoxication General Medicine Small intestine Rats Intestines 030104 developmental biology medicine.anatomical_structure Liver chemistry Blood-Brain Barrier Biologically active substances business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 168:38-40 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-019-04640-8 |
| Popis: | Myeloablative therapy was modeled by administration of cyclophosphamide to rats in a dose of 2.1 LD50 for 14 days. Under these conditions, increased accumulation of Evans blue dye given by gavage was observed in the blood, brain, lung, liver, kidney, and ileum (by 34, 1.6, 149, 46, 30, and 6.2 times, respectively). After intravenous injection of the dye, its accumulation was increased only in the lung and ileum. Thus, simulation of myeloablation cytostatic therapy by cyclophosphamide injection to rats is associated with impairment of the intestinal and lung-blood barriers. These alterations predispose to penetration of biologically active substances from the small intestine, gastrointestinal chyme, and lungs to the blood, thus contributing to the development of the early toxic effects of cyclophosphamide. |
| Databáze: | OpenAIRE |
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