Capecitabine-induced hyperammonemic encephalopathy
| Autor: | Francisco Xavier Cano Calderero, Carolina Cerrella Cano, Edisa María Armesto González, Eduardo Junquera Alonso, Marina Terroba Alonso, Lucía Seoane Blanco |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Side effect medicine.medical_treatment Adenocarcinoma Gastroenterology Capecitabine Ammonia Internal medicine Humans Hyperammonemia Medicine Aged Brain Diseases Chemotherapy business.industry General Medicine medicine.disease Discontinuation Pancreatic Neoplasms business Hyperammonemic encephalopathy After treatment medicine.drug |
| Zdroj: | Revista Española de Enfermedades Digestivas. |
| ISSN: | 1130-0108 |
| DOI: | 10.17235/reed.2021.8129/2021 |
| Popis: | We report the case of a 79-year-old male who had undergone surgery for a mucus-secreting, stage-III pancreatic adenocarcinoma 2 years previously, who was recently started on capecitabine monotherapy for radiographic local progression. He developed disorientation, asterixis, nausea and elevated serum ammonia (221 μmol/L) 48-72 hours after treatment onset with preserved liver function. After ruling out potential causes of encephalopathy and tumor progression by abdominal and brain CT scans, his symptoms were related by exclusion to the recently initiated treatment with capecitabine. Capecitabine discontinuation, onset of standard anti-encephalopathy measures, and intravenous hydration led to a rapid, complete resolution of symptoms with serum ammonia normalization. |
| Databáze: | OpenAIRE |
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