Correlation among Antioxidant, Antimicrobial, Hemolytic, and Antiproliferative Properties of Leiothrix spiralis Leaves Extract
| Autor: | Marcelo Gonzaga de Freitas Araújo, Taís Maria Bauab, Claudia Elena Sotomayor, Iguatemy Lourenço Brunetti, Wagner Vilegas, Felipe Hilário, Lourdes Campaner dos Santos |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp), Universidad Nacional de Córdoba |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Antioxidant
Erythrocytes antioxidant Hypha medicine.medical_treatment Flavonoid Leiothrix spiralis luteolin antimicrobial hemolytic citotoxicity Biology Secondary metabolite Hemolysis Catalysis Article Antioxidants Inorganic Chemistry chemistry.chemical_compound Botany Candida albicans Gram-Negative Bacteria medicine Humans Physical and Theoretical Chemistry Cytotoxicity Molecular Biology Spectroscopy chemistry.chemical_classification Reactive oxygen species Traditional medicine Plant Extracts Organic Chemistry General Medicine Antimicrobial Computer Science Applications Plant Leaves chemistry Eriocaulaceae Luteolin medicine.drug HeLa Cells |
| Zdroj: | International Journal of Molecular Sciences; Volume 13; Issue 7; Pages: 9260-9277 Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms13079260 |
| Popis: | Made available in DSpace on 2013-09-27T14:53:41Z (GMT). No. of bitstreams: 1 WOS000306760000042.pdf: 1414988 bytes, checksum: bced961216e0368970656e7bc08e0f7d (MD5) Previous issue date: 2012-07-01 Made available in DSpace on 2013-09-30T18:06:21Z (GMT). No. of bitstreams: 1 WOS000306760000042.pdf: 1414988 bytes, checksum: bced961216e0368970656e7bc08e0f7d (MD5) Previous issue date: 2012-07-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T14:21:08Z No. of bitstreams: 1 WOS000306760000042.pdf: 1414988 bytes, checksum: bced961216e0368970656e7bc08e0f7d (MD5) Made available in DSpace on 2014-05-20T14:21:08Z (GMT). No. of bitstreams: 1 WOS000306760000042.pdf: 1414988 bytes, checksum: bced961216e0368970656e7bc08e0f7d (MD5) Previous issue date: 2012-07-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) The biological activities of a plant extract depend on a complex sum of individual properties including the antioxidant activity. Several biological activities protect against the harmful action of reactive oxygen species (ROS), and here we focused our attention on the relationship between the biological activities tested and the antioxidant properties. In this study, the total flavonoid content as well as the antioxidant, antimicrobial, hemolytic and cytotoxicity activities of the methanolic extract of Leitothrix spiralis leaves were evaluated. The extract showed a total flavonoid content of 19.26% and the chemical characterization by HPLC-PAD confirmed the presence of flavonoids as the major secondary metabolite compounds. Significant antioxidant activity (IC50 = 1.743 mu g/mL +/- 0.063) was demonstrated and was effective against Gram-negative organisms and all Candida strains tested, and showed an ability to inhibit hyphal formation. Non-hemolytic and antiproliferative activity could be demonstrated. São Paulo State Univ UNESP, Dept Biol Sci, Fac Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil São Paulo State Univ UNESP, Inst Chem, Dept Organ Chem, BR-14800900 Araraquara, SP, Brazil São Paulo State Univ UNESP, Clin Anal Dept, Fac Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil Natl Univ Cordoba, Dept Clin Biochem, CIBICI CONICET, Fac Chem Sci, RA-5000 Cordoba, Argentina São Paulo State Univ UNESP, Dept Biol Sci, Fac Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil São Paulo State Univ UNESP, Inst Chem, Dept Organ Chem, BR-14800900 Araraquara, SP, Brazil São Paulo State Univ UNESP, Clin Anal Dept, Fac Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil |
| Databáze: | OpenAIRE |
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