Contrast-Enhanced Ultrasound Imaging Quantification of Adventitial Vasa Vasorum in a Rabbit Model of Varying Degrees of Atherosclerosis

Autor:	Chun-Ping Ning, Ruyou Zhang, Yanqing Peng, Xiaoying Li, Zongmin Li, Litao Sun, Zhenzhen Wang, Xuesong Han, Jiawei Tian, Meizheng Dang
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	CD31 Vascular Endothelial Growth Factor A Pathology medicine.medical_specialty Science 030204 cardiovascular system & hematology Article 03 medical and health sciences 0302 clinical medicine Image Processing Computer-Assisted Medicine Animals Endothelial dysfunction Ultrasonography Multidisciplinary business.industry Histocytochemistry Vasa Vasorum Ultrasound Histopathological analysis medicine.disease Atherosclerosis Immunohistochemistry Platelet Endothelial Cell Adhesion Molecule-1 Disease Models Animal medicine.anatomical_structure Carotid Arteries Vasa vasorum Rabbit model Rabbits business 030217 neurology & neurosurgery Contrast-enhanced ultrasound
Zdroj:	Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017) Scientific Reports
ISSN:	2045-2322
Popis:	This study used an atherosclerotic rabbit model to investigate the feasibility of quantifying adventitial vasa vasorum (VV) via contrast-enhanced ultrasound (CEUS) imaging to identify early atherosclerosis. Recent evidence has linked adventitial VV with atherosclerotic plaque progression and vulnerability. A growth in VV density has been detected preceding intimal thickening and even endothelial dysfunction. In our study, carotid atherosclerosis rabbit models were used, and animals underwent CEUS imaging at the end of the atherosclerotic induction period. Normalized maximal video-intensity enhancement (MVE) was calculated to quantify VV density. After CEUS imaging, animals were euthanized, and their carotids were processed for histopathological analysis following staining for CD31 and VEGF. Adventitial normalized MVE increased as atherosclerosis progressed (p p p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce69e4cf14a15dbd3c35b422195eea1 https://doaj.org/article/e83ff9a676884ed6826de7d44797bc55 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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