Do penile haemodynamics change in the presence of hydrogen sulphide (H2S) donor in metabolic syndrome-induced erectile dysfunction?
| Autor: | Nergiz Durmus, E. Dayar, Nil Hocaoglu, E. Kara, Gunay Yetik-Anacak, Sedef Gidener, Ozan Bozkurt |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Mean arterial pressure Waist business.industry Urology Hemodynamics Intracavernous injection General Medicine Intracavernous pressure 030204 cardiovascular system & hematology Hydrogen sulphide medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology Erectile dysfunction Internal medicine medicine Metabolic syndrome business |
| Popis: | Summary Erectile dysfunction (ED) is defined in relation to the metabolic syndrome (metS). Hydrogen sulphide (H2S), a gasotransmitter, has been revealed to get involved in hypertension, insulin secretion and regulation of vascular tone especially in erectile physiology. This study aimed to investigate the effect of H2S on metS-induced ED. Animals were divided into two groups as control and metS, which were fed with standard diet or 60% high-fructose diet for 10 weeks respectively. The metS model was evaluated with biochemical analyses, waist circumference/tibia length ratio and HOMA index. Penile hemodynamic parameters were evaluated by the measurement of intracavernous pressure/mean arterial pressure ratio during cavernous nerve stimulation in the presence and absence of intracavernous injection of NaHS (100 μg/50 μl) and its control 0.9%NaCl (50 μl) in both groups. H2S levels were measured in penile tissues by methylene blue assay. H2S levels were significantly decreased in the penile tissues of the metS group. Decreased intracavernous pressure/mean arterial pressure ratio improved after intracavernous administration of NaHS in the metS group. These results suggest the significant role of H2S in the metS-induced erectile dysfunction that could be a new therapeutic target. |
| Databáze: | OpenAIRE |
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