Low-dose thiamine supplementation of lactating Cambodian mothers improves human milk thiamine concentrations: a randomized controlled trial
| Autor: | Albert Koulman, Lindsay H. Allen, Sarah Meadows, Rem Ngik, Dare A. Baldwin, Jelisa Gallant, Prak Sophonneary, Timothy J. Green, Setareh Shahab-Ferdows, Lisa N Yelland, Kathleen Chan, Mam Borath, Daniela Hampel, Damon A Parkington, Hou Kroeun, Kerry S Jones, Frank T. Wieringa, Kyly C. Whitfield, Jeffrey R. Measelle, Shalem Leemaqz |
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| Přispěvatelé: | Hampel, Daniela [0000-0003-0288-7680], Allen, Lindsay H [0000-0002-8729-5213], Jones, Kerry S [0000-0002-7380-9797], Koulman, Albert [0000-0001-9998-051X], Meadows, Sarah R [0000-0001-5222-0257], Whitfield, Kyly C [0000-0001-8315-8927], Apollo - University of Cambridge Repository |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
and promotion of well-being Medicine (miscellaneous) Reproductive health and childbirth Medical and Health Sciences law.invention AcademicSubjects/MED00160 ThDP Engineering 0302 clinical medicine Randomized controlled trial law ETKac Medicine 030212 general & internal medicine Thiamine Nutrition and Dietetics thiamine (vitamin B1) Low dose food and beverages human milk Original Research Communications Milk 6.1 Pharmaceuticals Vitamin B Complex Female Cambodia Human Adult Clinical Trials and Supportive Activities thiamine AcademicSubjects/MED00060 03 medical and health sciences Young Adult Animal science Double-Blind Method Clinical Research Complementary and Integrative Health Humans 3.3 Nutrition and chemoprevention Nutrition Global Nutrition 030109 nutrition & dietetics Nutrition & Dietetics Milk Human business.industry Prevention Evaluation of treatments and therapeutic interventions Prevention of disease and conditions Good Health and Well Being supplementation Dietary Supplements business human activities Postpartum period |
| Zdroj: | The American journal of clinical nutrition, vol 114, iss 1 The American Journal of Clinical Nutrition |
| Popis: | BackgroundInfantile beriberi-related mortality is still common in South and Southeast Asia. Interventions to increase maternal thiamine intakes, and thus human milk thiamine, are warranted; however, the required dose remains unknown.ObjectivesWe sought to estimate the dose at which additional maternal intake of oral thiamine no longer meaningfully increased milk thiamine concentrations in infants at 24 wk postpartum, and to investigate the impact of 4 thiamine supplementation doses on milk and blood thiamine status biomarkers.MethodsIn this double-blind, 4-parallel arm randomized controlled dose-response trial, healthy mothers were recruited in Kampong Thom, Cambodia. At 2 wk postpartum, women were randomly assigned to consume 1 capsule, containing 0, 1.2 (estimated average requirement), 2.4, or 10 mg of thiamine daily from 2 through 24 weeks postpartum. Human milk total thiamine concentrations were measured using HPLC. An Emax curve was plotted, which was estimated using a nonlinear least squares model in an intention-to-treat analysis. Linear mixed-effects models were used to test for differences between treatment groups. Maternal and infant blood thiamine biomarkers were also assessed.ResultsIn total, each of 335 women was randomly assigned to1 of the following thiamine-dose groups: placebo (n=83), 1.2 mg (n=86), 2.4 mg (n=81), and 10 mg (n=85). The estimated dose required to reach 90% of the maximum average total thiamine concentration in human milk (191 µg/L) is 2.35 (95% CI: 0.58, 7.01) mg/d. The mean±SD milk thiamine concentrations were significantly higher in all intervention groups (183±91, 190±105, and 206±89 µg/L for 1.2, 2.4, and 10 mg, respectively) compared with the placebo group (153±85 µg/L; P |
| Databáze: | OpenAIRE |
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