Assessment of body composition in Wistar rat offspring by DXA in relation to prenatal and postnatal nutritional manipulation
| Autor: | George P. Chrousos, Kypros H. Nicolaides, Makarios Eleftheriades, Neil J. Sebire, George Vaggos, Ismene Dontas, Homeira Vafaei, Katerina Marinou, Panagiota Pervanidou |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Offspring Birth weight Intrauterine growth restriction Nutritional Status 030209 endocrinology & metabolism Diet High-Fat 03 medical and health sciences Random Allocation 0302 clinical medicine Absorptiometry Photon Pregnancy Internal medicine Lactation medicine Animals Birth Weight Obesity Rats Wistar Adiposity Fetus 030219 obstetrics & reproductive medicine Fetal Growth Retardation business.industry medicine.disease Rats Disease Models Animal Endocrinology medicine.anatomical_structure Animals Newborn Prenatal Exposure Delayed Effects Pediatrics Perinatology and Child Health Body Composition Gestation Pregnancy Animal Animal Nutritional Physiological Phenomena Female business Densitometry |
| Zdroj: | Pediatric research. 80(2) |
| ISSN: | 1530-0447 |
| Popis: | This experimental study aims to investigate the impact of combinations of prenatal and postnatal food manipulation on body composition in rat offspring. On day 12 of gestation, 100 timed pregnant rats were randomized into two nutritional groups: standard laboratory and 50% starved. Pups born to starved mothers were subdivided, based on birthweight (BiW), into fetal growth restricted (FGR) and non-FGR. Pups were born on day 21, cross-fostered, then left undisturbed lactating until the 26th postnatal day when they underwent dual-energy X-ray absorptiometry (DXA) examination. Prenatally control-fed animals had a significantly greater body weight at 26 d postnatally than the prenatally starved groups, irrespective of their postnatal diet (P < 0.001). Postnatal control diet was associated with significantly increased abdominal and total fat in non-FGR compared to FGR rats (P < 0.001). non-FGR/CONTROL rats showed higher values of abdominal fat than prenatally starved animals that were starved postnatally irrespective of their birth weight (P < 0.001). Postnatal control diet significantly increased total bone mineral content (BMC), head BMC, head area, abdominal BMC in non-FGR compared to FGR rats (P < 0.001). Interaction between prenatal and postnatal nutrition affects growth, abdominal adiposity, and bone accrual in Wistar rats’ offspring at 26 d of life. |
| Databáze: | OpenAIRE |
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