Competition for endothelial cell polarity drives vascular morphogenesis
| Autor: | Daniela Ramalho, I. Mauldin, I. Fortunato, L. H. Misikova, D. Barata, M. Dominguez-Cejudo, Miguel O. Bernabeu, Yulia Carvalho, Anna Pezzarossa, Catarina G Fonseca, Andreia Pena, Anne Eichmann, Pere Roca-Cusachs, Ylenia Giarratano, L. M. Faure, Xavier Trepat, Claudio A. Franco, M. Ouarne, Manuel Gomez-Gonzalez, Georgia Zarkada, Pedro Miguel Branco Barbacena |
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| Rok vydání: | 2021 |
| Předmět: |
Sprouting angiogenesis
History Polymers and Plastics Chemistry Polarity (physics) Industrial and Manufacturing Engineering Cell biology Adherens junction Endothelial stem cell Focal adhesion Vascular endothelial growth factor A medicine.anatomical_structure Cell polarity medicine Business and International Management Blood vessel |
| Zdroj: | bioRxiv BioRxiv |
| Popis: | Blood vessel formation generates unique vascular patterns in each individual. The principles governing the apparent stochasticity of this process remain to be elucidated. Using mathematical methods, we find that the transition between two fundamental vascular morphogenetic programs – sprouting angiogenesis and vascular remodeling – is established by a shift on collective front-rear polarity of endothelial cells. We demonstrate that the competition between biochemical (VEGFA) and mechanical (blood flow-induced shear stress) cues controls this collective polarity shift. Shear stress increases tension at focal adhesions overriding VEGFA-driven collective polarization, which relies on tension at adherens junctions. We propose that vascular morphogenetic cues compete to regulate individual cell polarity and migration through tension shifts that translates into tissue-level emergent behaviors, ultimately leading to uniquely organized vascular patterns. |
| Databáze: | OpenAIRE |
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