Cobalt-Cross-Linked, Redox-Responsive Spy Network Protein Hydrogels
| Autor: | Fei Sun, Songzi Kou, Xiaotian Liu, Xin Yang, Zhongguang Yang, Seraphine V. Wegner |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Polymers and Plastics
Chemistry Organic Chemistry chemistry.chemical_element 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Redox responsive 01 natural sciences Combinatorial chemistry 0104 chemical sciences law.invention Inorganic Chemistry law Self-healing hydrogels Materials Chemistry Recombinant DNA 0210 nano-technology Cobalt |
| Zdroj: | ACS Macro Letters. 8:773-778 |
| ISSN: | 2161-1653 |
| DOI: | 10.1021/acsmacrolett.9b00333 |
| Popis: | Although assembly of recombinant proteins by SpyTag/SpyCatcher chemistry has proven to be a versatile approach for creating bioactive hydrogels, the resulting Spy networks often exhibit weak mechanics due to the poor efficiency of interchain cross-linking. Here we leverage metal/ligand (i.e., cobalt/His6-tag) coordination interactions to modulate the bulk mechanics of the protein networks. The drastic difference between the Co |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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