Improving the compaction properties of roller compacted calcium carbonate
| Autor: | C. Bacher, Peder Mohr Olsen, Jørn M. Sonnergaard, J. Kristensen, Poul Bertelsen |
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| Rok vydání: | 2007 |
| Předmět: |
Materials science
Drug Industry Drug Compounding Compaction Pharmaceutical Science Mineralogy chemistry.chemical_element Calcium Calcium Carbonate Excipients chemistry.chemical_compound Granulation Pharmaceutic Aids Pressure Sorbitol Particle Size Composite material Consolidation (soil) Calcium carbonate chemistry Microscopy Electron Scanning Compressibility Particle size Powders Algorithms Stearic Acids Tablets |
| Zdroj: | International Journal of Pharmaceutics. 342:115-123 |
| ISSN: | 0378-5173 |
| Popis: | The effects of roller compaction process parameters, morphological forms of calcium carbonate and particle size of sorbitol on flow, compaction and compression properties were investigated. The morphology of the calcium carbonate and the sorbitol particle size were more influential on the compaction properties than the settings of the roller compactor. The roller compaction process was demonstrated to be robust and stable in regard to flowability and compactibility. The flowability of the granules was improved adequately to facilitate compression in a production scale rotary tablet press. By adding sorbitol to the calcium carbonate, the compressibility – characterized by the Walker coefficient W ID – and the compactibility C P were improved considerably. A correlation between the consolidation characteristics was demonstrated. Compactibility data from the compaction simulator correlated with the tablet press for two of the calcium carbonates, the cubic form and the ground quality. |
| Databáze: | OpenAIRE |
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