Lipoarabinomannan fromMycobacterium tuberculosismodulates the generation of reactive nitrogen intermediates by gamma interferon-activated macrophages
| Autor: | Patrick J. Brennan, Delphi Chatterjee, Francis E. Nano, Lawrence S. D. Anthony |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Lipopolysaccharides
Microbiology (medical) Lipopolysaccharide medicine.medical_treatment Immunology Nitric Oxide Microbiology Mycobacterium tuberculosis Interferon-gamma Mice chemistry.chemical_compound medicine Animals Immunology and Allergy Macrophage Interferon gamma Francisella tularensis Lipoarabinomannan biology General Medicine Macrophage Activation bacterial infections and mycoses biology.organism_classification Recombinant Proteins Mice Inbred C57BL Infectious Diseases Cytokine chemistry Female lipids (amino acids peptides and proteins) Growth inhibition medicine.drug |
| Zdroj: | FEMS Immunology & Medical Microbiology. 8:299-305 |
| ISSN: | 1574-695X 0928-8244 |
| DOI: | 10.1111/j.1574-695x.1994.tb00456.x |
| Popis: | Lipoarabinomannan derived from the virulent Erdman strain and a rapidly growing, laboratory-attenuated strain of Mycobacterium tuberculosis were evaluated for their ability to modulate the production of nitric oxide (NO) by macrophages activated with IFN-gamma or IFN-gamma and LPS. It was observed that in macrophages pretreated with 100 micrograms ml-1 LAM, the NO induced by IFN-gamma alone was augmented while the NO induced IFN-gamma and LPS was reduced. LAM was also shown to synergize with IFN-gamma in the induction of NO, with AraLAM from the attenuated strain exhibiting greater potency than ManLAM from the Erdman strain. Despite the modulation of NO production, LAM did not affect the IFN-gamma-induced macrophage growth inhibition of Francisella tularensis LVS, an organism whose growth inhibition in activated macrophages is dependent upon NO. |
| Databáze: | OpenAIRE |
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