Pyrido[2,1-b]quinazolinecarboxylic acids as orally active antiallergy agents

Autor:	Richard W. Kierstead, M. Carson, Herman W. Baruth, Bohdan Yaremko, Jefferson Wright Tilley, Ronald Andrew Lemahieu
Rok vydání:	1980
Předmět:	Male Chemistry Passive Cutaneous Anaphylaxis Nickel Carbonyl Administration Oral Antiallergy Agents Medicinal chemistry Rats Structure-Activity Relationship Orally active Carboxylation Drug Discovery Hypersensitivity Quinazolines Animals Molecular Medicine Structure–activity relationship
Zdroj:	Journal of Medicinal Chemistry. 23:92-95
ISSN:	1520-4804 0022-2623
Popis:	A series of 8-substituted pyrido[2,1-]quinazoline-2-carboxylic acids was prepared by the nickel carbonyl mediated carboxylation of the corresponding bromides. The activities of these compounds in the rat PCA test are comparable to those of the corresponding 2-substituted pyrido[2,1-b]quinazoline-8-carboxylic acids.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd8d67be7fc7f968ed722c069180bb5 https://doi.org/10.1021/jm00175a020 Zobrazit plný text záznamu