Changes in arterial stiffness, carotid intima-media thickness, and epicardial fat after L-thyroxine replacement therapy in hypothyroidism
| Autor: | Cristina Victoria Hernández-Roca, Jorge Luis González-Valdés, Julio Oscar Cabrera-Rego, Lisván Carrero-Fernández, Abdel del Busto-Mesa, José Eduardo de la Rosa-Pazos |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Very low-density lipoprotein endocrine system diseases Hormone Replacement Therapy Carotid Intima-Media Thickness Vascular Stiffness Hypothyroidism Internal medicine medicine Humans Euthyroid Prospective Studies Pulse wave velocity business.industry Primary hypothyroidism medicine.disease Thyroxine Blood pressure Intima-media thickness Adipose Tissue cardiovascular system Cardiology Arterial stiffness lipids (amino acids peptides and proteins) Female business Pericardium Dyslipidemia |
| Zdroj: | Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion. 62(6) |
| ISSN: | 1579-2021 |
| Popis: | Objective To assess the relationship between primary hypothyroidism and subclinical atherosclerosis and its potential changes with L-thyroxine replacement therapy. Methods A prospective cohort study including 101 patients with primary hypothyroidism and 101 euthyroid patients as controls was conducted from July 2011 to December 2013. Clinical, anthropometrical, biochemical, and ultrasonographic parameters were assessed at baseline and after one year of L-thyroxine replacement therapy. Results At baseline, hypothyroid patients had significantly greater values of blood pressure, total cholesterol, VLDL cholesterol, left ventricular mass, epicardial fat, and carotid intima-media thickness as compared to controls. Total cholesterol, VLDL cholesterol, ventricular diastolic function, epicardial fat, carotid intima-media thickness, carotid local pulse wave velocity, pressure strain elastic modulus, and β arterial stiffness index showed a significant and positive correlation with TSH levels. After one year of replacement therapy, patients with hypothyroidism showed changes in total cholesterol, VLDL cholesterol, TSH, carotid intima-media thickness, and arterial stiffness parameters. Conclusions Primary hypothyroidism is characterized by an increased cardiovascular risk. In these patients, L-thyroxine replacement therapy for one year is related to decreased dyslipidemia and improvement in markers of subclinical carotid atherosclerosis. |
| Databáze: | OpenAIRE |
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