Organophosphate pesticide exposure, hormone levels, and interaction with PON1 polymorphisms in male adolescents
| Autor: | B. Suárez, F. Vela-Soria, José Gómez-Vida, Darío Acuña-Castroviejo, Alicia Olivas-Martínez, Mariana F. Fernández, Carmen Freire, Francesca Castiello, Nicolás Olea |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Insecticides endocrine system medicine.medical_specialty Environmental Engineering Adolescent 010504 meteorology & atmospheric sciences 010501 environmental sciences 01 natural sciences chemistry.chemical_compound Follicle-stimulating hormone Organophosphorus Compounds Sex hormone-binding globulin Thyroid-stimulating hormone Internal medicine medicine Humans Environmental Chemistry Pesticides Child Waste Management and Disposal 0105 earth and related environmental sciences Triiodothyronine biology Aryldialkylphosphatase business.industry Pollution Prolactin TCPy Endocrinology chemistry Spain biology.protein Follicle Stimulating Hormone business Luteinizing hormone hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Science of The Total Environment. 769:144563 |
| ISSN: | 0048-9697 |
| Popis: | Objective To examine the association between urinary metabolites of organophosphate (OP) pesticides and serum concentrations of thyroid and reproductive hormones in male adolescents and to assess the potential effect of interactions between OP pesticides and paraoxonase 1 (PON1) polymorphisms on hormone levels. Methods Study subjects (N = 117) were male 16- to 17-year-olds from the Environment and Childhood (INMA)-Granada cohort in Spain. Concentrations of 3,5,6-trichloro-2-pyridinol (TCPy), a metabolite of chlorpyrifos/chlorpyrifos-methyl, 2-isopropyl-6-methyl-4-pyrimidinol (IMPy), a metabolite of diazinon, and diethylthiophosphate (DETP) and diethyldithiophosphate (DEDTP), non-specific metabolites of OP pesticides, were measured in a spot urine sample from each subject and adjusted for creatinine. Levels of reproductive hormones (total testosterone [TT], estradiol [E2], dehydroepiandrosterone sulfate [DHEAS], sex hormone binding globulin [SHBG], luteinizing hormone [LH], follicle stimulating hormone [FSH], anti-Mullerian hormone [AMH], insulin growth factor 1 [IGF-1], and prolactin), thyroid hormones (free thyroxine [FT4], total triiodothyronine [TT3], and thyroid stimulating hormone [TSH]), and PON1 Q192R and L55M polymorphisms were determined in blood drawn during the same clinical visit. Results Multiple linear regression models showed that detectable levels of TCPy were associated with an increase in DHEAS and decreases in E2, FSH, and AMH; detectable IMPy with increases in E2, DHEAS, FSH, AMH, and prolactin and decreases in SHBG and LH; and detectable DETP with marginally-significant increases in TT and TT3 and decreases in FSH, AMH, and prolactin. The effect of IMPy and DETP on DHEAS and TT levels, respectively, was higher in subjects that carried the PON1 55MM genotype, while the effect of TCPy, IMPy, and DETP on thyroid hormone levels was higher in PON1 192QR/RR or 55MM genotype carriers. Conclusions In male adolescents, non-occupational exposure to OP pesticides was associated with several changes in reproductive and thyroid hormone levels, and the magnitude of some associations was greater in adolescents genetically more susceptible to OP pesticide exposure who carry the PON1 55MM genotype. |
| Databáze: | OpenAIRE |
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