Association of obstructive sleep apnea with homocystein, nitric oxide and total antioxidant capacity levels in patients with or without coronary artery disease
| Autor: | Yeşim Özkan, Recai Ergün, Hikmet Firat, Sadik Ardic, Sevgi Akaydin, Mine Durusu, Gülbahar Darılmaz Yüce, Arzu Topeli, Ebru Ortaç Ersoy |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Homocysteine Polysomnography CAD Coronary Artery Disease Nitric Oxide Critical Care and Intensive Care Medicine Antioxidants Coronary artery disease Pathogenesis chemistry.chemical_compound stomatognathic system Internal medicine medicine Humans cardiovascular diseases Myocardial infarction Sleep Apnea Obstructive medicine.diagnostic_test business.industry Sleep apnea Middle Aged medicine.disease nervous system diseases respiratory tract diseases Obstructive sleep apnea chemistry Anesthesia Cardiology Female Surgery business |
| Zdroj: | Tuberk Toraks. 62:207-214 |
| ISSN: | 0494-1373 |
| DOI: | 10.5578/tt.7845 |
| Popis: | INTRODUCTION: Obstructive sleep apnea (OSA) is associated with cardiovascular morbidity and mortality. Deficiency of nitric oxide (NO) and plasma levels of homocystein have been implicated in the pathogenesis of cardiovascular disease. OSA results in oxygen desaturation and arousal from sleep. Free oxygen radicals can be produced by hypoxia-reoxygenation. To test for the hypothesis that OSA is associated with cardiovascular morbidity, we investigated levels of homocystein, NO and total antioxidant capacity in OSA patients with and without coronary artery disease (CAD) in comparison with normal subjects and patients with CAD without OSA. MATERIALS AND METHODS: Polysomnography was performed in 27 patients who had a myocardial infarction and in 25 patients without evidence of CAD. Patients were grouped according their polysomnography results as OSA with CAD (group 1), OSA without CAD (group 2), CAD (group 3), and normal (group 4) . Levels of homocystein, NO and total antioxidant capacity were determined after an overnight fasting. Data were analysed with parametric and non parametric statistical tests. RESULTS: According to apnea-hypopnea index (AHI) 44.4% of CAD patients were OSA. After polysomnographic evaluation, the patients were re-distributed as follows: OSA with CAD (n= 12), OSA without CAD (n= 14), CAD (n= 15), and normal (n= 11). Homocystein levels were higher in 3 groups compared to controls. AHI, MDI and desaturation time was higher in three -vessel disease compared to one and two- vessel diseases (p< 0.05). NO levels were correlated with the period of oxygen desaturation (r: -0.45, p= 0.031). The antioxidant capacity did not differ between OSA and healthy groups. CONCLUSION: OSA is frequent in CAD. AHI, MDI and desaturation time are higher in patients with severe CAD. It is important to evaluate OSA patients for CAD. |
| Databáze: | OpenAIRE |
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