Manganese(III) Porphyrin-based Potentiometric Sensors for Diclofenac Assay in Pharmaceutical Preparations
| Autor: | Elena Maria Pica, Eugenia Fagadar-Cosma, Florina Pogacean, Liviu Calin Bolundut, Liliana Olenic, Vasile Ostafe, Vlad Chiriac, Dana Vlascici, Stela Pruneanu, Luminita Nica |
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| Rok vydání: | 2010 |
| Předmět: |
manganese porphyrins
Metalloporphyrins Potentiometric titration Inorganic chemistry chemistry.chemical_element Manganese pharmaceuticals lcsh:Chemical technology Biochemistry Chloride Article Analytical Chemistry chemistry.chemical_compound diclofenac ion–selective electrodes potentiometry electrochemical impedance spectroscopy Tetraphenylporphyrin medicine lcsh:TP1-1185 Electrical and Electronic Engineering Electrodes Instrumentation Detection limit Plasticizer Porphyrin Atomic and Molecular Physics and Optics chemistry Sodium tetraphenylborate medicine.drug |
| Zdroj: | Sensors, Vol 10, Iss 10, Pp 8850-8864 (2010) Sensors; Volume 10; Issue 10; Pages: 8850-8864 Sensors (Basel, Switzerland) |
| ISSN: | 1424-8220 |
| DOI: | 10.3390/s101008850 |
| Popis: | Two manganese(III) porphyrins: manganese(III) tetraphenylporphyrin chloride and manganese(III)-tetrakis(3-hydroxyphenyl)porphyrin chloride were tested as ionophores for the construction of new diclofenac-selective electrodes. The electroactive material was incorporated either in PVC or a sol-gel matrix. The effect of different plasticizers and additives (anionic and cationic) on the potentiometric response was studied. The best results were obtained for the PVC membrane plasticized with dioctylphtalate and having sodium tetraphenylborate as a lipophilic anionic additive incorporated. The sensor response was linear in the concentration range 3 × 10(-6) - 1 × 10(-2) M with a slope of -59.7 mV/dec diclofenac, a detection limit of 1.5 × 10(-6) M and very good selectivity coefficients. It was used for the determination of diclofenac in pharmaceutical preparations, by direct potentiometry. The results were compared with those obtained by the HPLC reference method and a good agreement was found between the two methods. |
| Databáze: | OpenAIRE |
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