Polyhydroxyalkanoate‐associated phasins as phylogenetically heterogeneous, multipurpose proteins
| Autor: | Jesús Sanz, Beatriz Maestro |
|---|---|
| Přispěvatelé: | Departamentos de la UMH::Bioquímica y Biología Molecular, Instituto de Biología Molecular y Celular |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
lcsh:Biotechnology 030106 microbiology Bioengineering Biology Applied Microbiology and Biotechnology Biochemistry Inclusion bodies Polyhydroxyalkanoates 03 medical and health sciences Bacterial Proteins lcsh:TP248.13-248.65 Amphiphile Phylogeny chemistry.chemical_classification Bacteria Granule (cell biology) Minireviews Enzyme chemistry Cytoplasm PHA granule Minireview PHA metabolism 57 - Biología Plant Lectins Biotechnology |
| Zdroj: | REDIUMH. Depósito Digital de la UMH instname Microbial Biotechnology Microbial Biotechnology, Vol 10, Iss 6, Pp 1323-1337 (2017) |
| Popis: | Polyhydroxyalkanoates (PHAs) are natural polyesters of increasing biotechnological importance that are synthesized by many prokaryotic organisms as carbon and energy storage compounds in limiting growth conditions. PHAs accumulate intracellularly in form of inclusion bodies that are covered with a proteinaceous surface layer (granule-associated proteins or GAPs) conforming a network-like surface of structural, metabolic and regulatory polypeptides, and configuring the PHA granules as complex and well-organized subcellular structures that have been designated as ‘carbonosomes’. GAPs include several enzymes related to PHA metabolism (synthases, depolymerases and hydroxylases) together with the so-called phasins, an heterogeneous group of smallsize proteins that cover most of the PHA granule and that are devoid of catalytic functions but nevertheless play an essential role in granule structure and PHA metabolism. Structurally, phasins are amphiphilic proteins that shield the hydrophobic polymer from the cytoplasm. Here, we summarize the characteristics of the different phasins identified so far from PHA producer organisms and highlight the diverse opportunities that they offer in the Biotechnology field. This work was supported by grants BIO2013-47684-R BIO2016- 79323-R (Spanish Ministry of Economy and Competitiveness |
| Databáze: | OpenAIRE |
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