Association of the SOD2 polymorphism (Val6Ala) and SOD activity with vaso-occlusive crisis and acute splenic sequestration in children with sickle cell anemia
| Autor: | Kleyton Palmeira do Ó, Taciana Furtado Mendonça-Belmont, Isabela Cristina Cordeiro Farias, Patrícia Muniz Mendes Freire de Moura, Fernanda Silva Medeiros, Maria do Socorro de Mendonça Cavalcanti, Ana Claudia Mendonça dos Anjos, Betânia Lucena Domingues Hatzlhofer, Aderson S Araujo, Luydson Richardson Silva Vasconcelos, Felipe A. B. S. Ferreira, Marcos André Cavalcanti Bezerra, Andreia Soares da Silva |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty SOD2 Gastroenterology Superoxide dismutase 03 medical and health sciences 0302 clinical medicine Internal medicine Genotype medicine Splenic sequestration In patient biology Sickle cell anemia vaso-occlusive crisis splenic sequestration SOD2 polymorphism lcsh:RC633-647.5 business.industry lcsh:Diseases of the blood and blood-forming organs Hematology medicine.disease Pathophysiology Sickle cell anemia 030104 developmental biology Infectious Diseases biology.protein business Vaso-occlusive crisis 030217 neurology & neurosurgery |
| Zdroj: | Mediterranean Journal of Hematology and Infectious Diseases, Vol 10, Iss 1, Pp e2018012-e2018012 (2018) |
| ISSN: | 2035-3006 |
| Popis: | The SOD2 polymorphism Val16Ala TàC influences the antioxidative response. This study investigated the association of the SOD2 polymorphism and superoxide dismutase (SOD) activity with vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One hundred ninety-five children aged 1-9 years old were analyzed. The TC and CC genotypes were associated with lower SOD activity compared with the TT genotype (p=0.0321; p=0.0253, respectively). Furthermore, TC/CC were more frequent in patients with VOC or ASS (p=0.0285; p=0.0090, respectively). These results suggest that the SOD2 polymorphism associated with low SOD activity could be involved in SCA physiopathology. |
| Databáze: | OpenAIRE |
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