Longstanding complex regional pain syndrome is associated with activating autoantibodies against alpha-1a adrenoceptors
| Autor: | Angela Vincent, David J. Greensmith, Martin Leuwer, Victoria Thompson, Maria Isabella Leite, Anoop Kuttikat, Andreas Goebel, Christian Maihöfner, Nicolas Shenker, Eric Dubuis, Franz Blaes |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Atropine Male medicine.medical_specialty Patch-Clamp Techniques Muscarinic Antagonists Transfection Immunoglobulin G Calcium in biology Membrane Potentials Dioxanes Young Adult Internal medicine Receptors Adrenergic alpha-1 Calcium flux medicine Animals Humans Myocytes Cardiac Receptor Cells Cultured Autoantibodies Cross-Over Studies biology business.industry Autoantibody Immunoglobulins Intravenous Middle Aged medicine.disease Rats Anesthesiology and Pain Medicine Complex regional pain syndrome Endocrinology Neurology IgG binding biology.protein Calcium Female Neurology (clinical) Antibody business Complex Regional Pain Syndromes Protein Binding |
| Zdroj: | Pain. 155(11) |
| ISSN: | 1872-6623 |
| Popis: | Complex regional pain syndrome (CRPS) is a limb-confined posttraumatic pain syndrome with sympathetic features. The cause is unknown, but the results of a randomized crossover trial on low-dose intravenous immunoglobulins (IVIG) treatment point to a possible autoimmune mechanism. We tested purified serum immunoglobulin G (IgG) from patients with longstanding CRPS for evidence of antibodies interacting with autonomic receptors on adult primary cardiomyocytes, comparing with control IgG from healthy and diseased controls, and related the results to the clinical response to treatment with low-dose IVIG. We simultaneously recorded both single-cell contractions and intracellular calcium handling in an electrical field. Ten of 18 CRPS preparations and only 1/57 control preparations (P |
| Databáze: | OpenAIRE |
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