Relationship between progression to AIDS and thrombophilic abnormalities in HIV infection
| Autor: | Rita R. Georg, Willem M. Lijfering, Piet A. van der Meulen, Herman G. Sprenger, Jan van der Meer |
|---|---|
| Přispěvatelé: | Faculteit Medische Wetenschappen/UMCG |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty PULMONARY-EMBOLISM Clinical Biochemistry HIV Infections Fibrinogen Thrombophilia Gastroenterology Risk Assessment DISEASE Acquired immunodeficiency syndrome (AIDS) Protein C deficiency Internal medicine medicine Coagulopathy Humans Protein S deficiency DEEP-VEIN THROMBOSIS Aged Retrospective Studies Venous Thrombosis Acquired Immunodeficiency Syndrome VENOUS THROMBOEMBOLISM ACTIVE ANTIRETROVIRAL THERAPY business.industry Biochemistry (medical) NECROSIS-FACTOR-ALPHA Thrombosis Middle Aged medicine.disease Pulmonary embolism Immunology HUMAN-IMMUNODEFICIENCY-VIRUS Female business ARTERIAL THROMBOSIS PROTEIN-S DEFICIENCY ELEVATED LEVELS medicine.drug |
| Zdroj: | Clinical Chemistry, 54(7), 1226-1233. AMER ASSOC CLINICAL CHEMISTRY |
| ISSN: | 0009-9147 |
| DOI: | 10.1373/clinchem.2008.103614 |
| Popis: | Background: HIV-infected patients are at increased risk of venous and arterial thrombosis. We hypothesized that acquired thrombophilic abnormalities that could predispose to thrombosis are most pronounced in patients in advanced stages of HIV infection. Methods: We included 109 consecutive HIV-infected patients in the study and tested them twice for currently known thrombophilic abnormalities at an interval of at least 3 months (median, 3 months; range, 3–12 months). Detailed information was collected about the date of diagnosis of HIV infection, HIV treatment, and previous episodes of venous and arterial thrombosis. Results: After HIV infection was diagnosed, 16% of the patients experienced symptomatic thrombosis (venous, 10%; arterial, 6%). Repeated measurements established protein C deficiency in 9% of the patients, increased factor VIII concentrations in 41%, high fibrinogen concentrations in 22%, and free protein S deficiency in 60%. Median factor VIII concentrations were higher in patients with AIDS (CD4 cell counts Conclusions: Multiple acquired and persistent thrombophilic abnormalities are more frequently observed in HIV-infected patients than in the healthy population. The frequencies of these thrombophilic abnormalities increase with the progression to AIDS. These findings may contribute to the high prevalence of venous and arterial thrombosis in HIV-infected patients. |
| Databáze: | OpenAIRE |
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