Cerebrospinal Fluid Neopterin Levels in Children with Central Nervous System Leukemia
| Autor: | J. L. Auget, Francoise Mechinaud, Francis Bauters, J-L Harousseau, Frédéric Millot, J. L. Dhondt, F. Mazingue |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Cancer Research Adolescent Blast Count Neopterin chemistry.chemical_compound Meninges Cerebrospinal fluid Leukemic Infiltration immune system diseases Precursor cell Biomarkers Tumor Meningeal Neoplasms Humans Medicine Malignant cells In patient Central nervous system leukemia Child Normal range Immunity Cellular Phagocytes business.industry Lymphoma Non-Hodgkin Infant Cerebrospinal Fluid Proteins Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma Prognosis Biopterin Burkitt Lymphoma Neoplasm Proteins Oncology chemistry Child Preschool Immunology Female business |
| Zdroj: | Leukemia & Lymphoma. 9:351-356 |
| ISSN: | 1029-2403 1042-8194 |
| Popis: | Cerebrospinal fluid (CSF) neopterin levels were determined by high-pressure liquid chromatography in 48 normal children and in 15 children with meningeal relapse of hematologic malignancies (13 acute lymphoblastic leukemia and 2 high-grade lymphomas). When meningeal relapse was diagnosed, all patients had CSF neopterin levels higher than mean normal value +2 standard deviations. No significant correlation between the blast count in the CSF and neopterin levels was observed. CSF data before relapse were available in 10 children: the neopterin values at relapse were significantly higher than values observed at diagnosis. In 3 patients, elevated neopterin levels preceded the occurrence of neurologic signs and the detection of blast cells in CSF by 15 to 30 days. In the absence of infection, the rise of CSF neopterin levels in patients with hematologic malignancies indicates an active phase of the disease. This could reflect a cell-mediated immunologic process induced by malignant cells. The measurement of CSF neopterin should be helpful in the monitoring of patients to detect early meningeal relapse. |
| Databáze: | OpenAIRE |
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