Nizatidine Suppression of Basal Gastric Acid Output: A Comparison of Two Intravenous Dosage Regimens

Autor: Kevin M. Furmaga, James H. Fischer, C. Thomas Bombeck, Keith A. Rodvold, Larry H. Danziger
Rok vydání: 1989
Předmět:
Zdroj: The Journal of Clinical Pharmacology. 29:946-952
ISSN: 0091-2700
DOI: 10.1002/j.1552-4604.1989.tb03259.x
Popis: To study the pharmacokinetics and pharmacodynamics of two intravenous nizatidine dosing regimens, serial plasma concentrations and continuous intragastric pH were monitored simultaneously in 10 subjects with a documented history of duodenal or gastric ulcers. A 24-hour gastric pH profile was characterized for a 300 mg daily dose of nizatidine randomly administered both as 100 mg every 8 hours and 150 mg every 12 hours. No significant differences were observed in the mean pharmacokinetic parameters between the two dosing regimens. Pharmacodynamic parameters for the 100 mg every 8 hours versus the 150 mg every 12 hours regimen were not significantly different except for percent of time during the 24-hour study period that the pH was maintained greater than 4 (43.6 +/- 20.7 versus 34.7 +/- 18.3, P less than .05). A significant relationship was demonstrated for both regimens (P less than .05) between the percent time pH greater than 4 and area under the plasma curve for the 24 hour study period. The lack of a significant difference in nizatidine pharmacokinetics between the two dosage regimens suggests a pharmacodynamic cause for the greater cumulative pH effect of the every 8 hour regimen.
Databáze: OpenAIRE
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