Blood Pressure Responses to Sucrose Ingestion in Four Rat Strains
| Autor: | Gilbert W. Gleim, Joseph Knapka, Beth W. Glace, Mohmed Zein, Philip MacArthy, Harry G. Preuss, Zofia Zukowska-Grojec, Ayub K. Yousufi |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Sucrose medicine.medical_specialty Epinephrine Systole medicine.medical_treatment Carbohydrates Administration Oral Blood Pressure Rats Inbred WKY Plasma renin activity Blood Urea Nitrogen Excretion Norepinephrine chemistry.chemical_compound Rats Inbred SHR Internal medicine Renin Internal Medicine medicine Animals Ingestion Neuropeptide Y cardiovascular diseases Aldosterone Kidney business.industry Insulin Body Weight Rats Inbred Strains Creatine Neuropeptide Y receptor Rats medicine.anatomical_structure Endocrinology Blood pressure chemistry business circulatory and respiratory physiology |
| Zdroj: | American Journal of Hypertension. 5:244-250 |
| ISSN: | 1941-7225 0895-7061 |
| DOI: | 10.1093/ajh/5.4.244 |
| Popis: | Among four strains examined, spontaneously hypertensive rats (SHR) show a marked (20 mm Hg, P less than .01) systolic blood pressure elevation (SBP), Sprague-Dawley (SD) and Wistar-Kyoto (WKY) rats developed a moderate elevation (8 mm Hg, P less than .01), and a normotensive Wistar rat (WAM) had a lesser SBP elevation (6 mm Hg, P = NS) after excess sucrose ingestion. The SBP elevations found in SHR were noted at 2 and 4 weeks after starting the dietary treatments. Corresponding with SBP changes, plasma renin activity (PRA), aldosterone, and neuropeptide Y (NPY) concentrations all decreased with the high sucrose-low protein diet compared to the low sucrose-high protein diet, while circulating insulin levels were unchanged. Although norepinephrine (NE) and epinephrine (E) excretion tended to be higher in the rats eating the high sucrose-low protein food, the differences were not statistically significant. The differences in these parameters could influence the SBP in SHR, SD, and WKY, but virtually similar qualitative and quantitative blood and urinary findings were found in WAM, a strain of rat that showed no significantly increased SBP. Removing one kidney increases the CHO-induced SBP response of WKY to levels comparable to those seen in SHR, converting a moderate responder to a highly sensitive one. We conclude that under well-controlled conditions there are obvious differences in the SBP response to the macronutrients in the diets of various rat strains and that SHR possess some intrinsic mechanism(s), most likely associated with renal metabolism, which make this strain more sensitive to refine CHO-induced SBP elevations. |
| Databáze: | OpenAIRE |
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