Diffusion tensor imaging and tractography of the white matter in normal aging

Autor: B Kremer, Johanna Mårtensson, Helgi B. Schiöth, Elna-Marie Larsson, Mats Fredrikson, Jelmer G. Kok, Jimmy Lätt, Hedvig Söderlund, Danielle van Westen, Maria Nilsson, Fredrik Åhs
Přispěvatelé: Molecular Neuroscience and Ageing Research (MOLAR)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Adult
Male
Aging
Adolescent
Biomedical Engineering
Biophysics
FRACTIONAL ANISOTROPY
Biology
Diffusion Anisotropy
030218 nuclear medicine & medical imaging
CORTICOSPINAL TRACT
White matter
03 medical and health sciences
Young Adult
0302 clinical medicine
Cingulum
AGE
Fractional anisotropy
Fasciculus
medicine
Cingulum (brain)
Humans
Radiology
Nuclear Medicine and imaging
Inferior fronto-occipital fasciculus
White matter degeneration
CINGULUM BUNDLE
Aged
LIFE-SPAN
Aged
80 and over
White matter tract
FRONTO-OCCIPITAL FASCICULUS
Anatomy
Middle Aged
biology.organism_classification
HUMAN BRAIN
White Matter
STATISTICS
ANATOMY
medicine.anatomical_structure
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
Corticospinal tract
VOLUME
Female
Tractography
030217 neurology & neurosurgery
Diffusion MRI
Zdroj: Magnetic Resonance Imaging, 45, 113-119. ELSEVIER SCIENCE INC
ISSN: 0730-725X
DOI: 10.1016/j.mri.2017.03.007
Popis: Knowledge concerning the normal aging of cerebral white matter will improve our understanding of abnormal changes in neurodegenerative diseases. The microstructural basis of white matter maturation and aging can be investigated using diffusion tensor imaging (DTI). Generally, diffusion anisotropy increases during childhood and adolescence followed by a decline in middle age. However, this process is subject to spatial variations between tracts. The aim of this study was to investigate to what extent age-related variations also occur within tracts. DTI parameters were compared between segments of two white matter tracts, the cingulate bundle (CB) and the inferior fronto-occipital fasciculus (IFO), in 257 healthy individuals between 13 and 84 years of age. Segments of the CB and the IFO were extracted and parameters for each segment were averaged across the hemispheres. The data was analysed as a function of age. Results show that age-related changes differ both between and within individual tracts. Different age trajectories were observed in all segments of the analysed tracts for all DTI parameters. In conclusion, aging does not affect white matter tracts uniformly but is regionally specific; both between and within white matter tracts. (C) 2017 Elsevier Inc. All rights reserved.
Databáze: OpenAIRE
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